中国免疫学杂志2026，Vol.42Issue(4)：997-1002,6.DOI:10.3969/j.issn.1000-484X.2026.04.036
溶瘤病毒在肿瘤治疗策略中的创新与挑战
Innovations and challenges of oncolytic viruses in cancer treatment strategies
摘要
Abstract
Oncolytic viruses(OVs),as an innovative strategy for cancer immunotherapy,are increasingly demonstrating sig-nificant potential in cancer treatment due to their high efficacy,precise tumor targeting,and relatively low side effects.This article provides a comprehensive review of the evolution of OV treatment strategies,scientific foundations,genetic engineering modifica-tions,clinical application strategies,and the potential for synergistic effects when used in combination with other therapeutic ap-proaches.It also discusses the challenges faced by OVs in the clinical translation process,including safety,efficacy assessment,and selection of viral vectors.In addition,the article introduces several commercialized OV drugs,such as H101,T-VEC and Delytact,which have shown positive therapeutic effects in the treatment of various types of cancer.The aim of this article is to explore innovative applications of OVs in cancer treatment and the challenges they face,providing a comprehensive perspective for researchers in the fields of immunology and oncology,in order to promote the scientific development and clinical application of this therapy.关键词
溶瘤病毒/肿瘤免疫治疗/治疗挑战/基因工程改造Key words
Oncolytic viruses/Cancer immunotherapy/Therapeutic challenges/Genetic engineering modification分类
医药卫生引用本文复制引用
张典,汪洋,李建全,高兴春..溶瘤病毒在肿瘤治疗策略中的创新与挑战[J].中国免疫学杂志,2026,42(4):997-1002,6.基金项目
国家自然科学基金面上项目(11971281). （11971281）
