中国免疫学杂志2026，Vol.42Issue(4)：1009-1015,7.DOI:10.3969/j.issn.1000-484X.2026.04.038
可诱导共刺激分子的作用机制及其在器官纤维化中的研究进展
Mechanisms of inducible costimulators and their advances in organ fibrosis
摘要
Abstract
Fibrosis is a common condition in chronic diseases,characterized by a reduction in parenchymal cell necrosis and an abnormal increase in extracellular matrix,leading to the destruction of organ structure and causing organ failure,the underlying mechanisms of its pathogenesis are currently unclear.Inducible costimulators(ICOS),members of the CD28 family,promote T cell proliferation,differentiation,and the release of various cytokines upon binding to their ligands,thus participating in the regulation of the body's immune response,who play a crucial role in various diseases,including tumor and rheumatoid arthritis.This paper focuses on the mechanisms of ICOS signal transduction and immunoregulation,as well as their role in organ fibrosis,providing a theoretical basis for a deeper understanding of the formation of fibrosis.关键词
可诱导共刺激分子/信号传导/器官纤维化/免疫细胞Key words
Inducible costimulator/Signal transduction/Organ fibrosis/Immune cells分类
医药卫生引用本文复制引用
都昌乐,王瑜..可诱导共刺激分子的作用机制及其在器官纤维化中的研究进展[J].中国免疫学杂志,2026,42(4):1009-1015,7.基金项目
安徽省高校自然科学研究重点项目(2024AH051717) （2024AH051717）
淮南联合大学自然科学研究项目(LQN2303). （LQN2303）
