中国输血杂志2026，Vol.39Issue(4)：557-563,7.DOI:10.13303/j.cjbt.issn.1004-549x.2026.04.021
自噬与血小板:机制、功能及相关疾病研究进展
Autophagy and platelets:mechanisms,functions,and research advances in related diseases
摘要
Abstract
Platelets are small,anucleated cells generated by cytoplasmic fragmentation and shedding from mature megakaryocytes.Upon vascular stimulation or injury,platelets become activated and adhere to exposed vascular endothelial cells,ultimately forming thrombi to promote blood coagulation and wound healing.In recent years,increasing evidence from in-depth studies on platelet function has revealed that autophagy plays a crucial role in platelet production and functional performance.Autophagy is an intracellular process of material recycling and reuse,involving autophagosome formation,car-go degradation,and nutrient recycling,which facilitates the maintenance of homeostasis and defense against pathogen infec-tion.Numerous studies have demonstrated that autophagy participates in the regulation of platelet production,activation,and aggregation,and is closely implicated in the pathogenesis of platelet dysfunction-related diseases such as immune throm-bocytopenia.Additionally,platelet-rich plasma therapy,by modulating the autophagic process,has shown great potential in treating osteoarthritis and promoting diabetic foot wound healing.This review thoroughly explores the potential roles of autoph-agy in regulating platelet production and function,as well as in platelet-related diseases.Future research should focus on the molecular mechanisms of platelet autophagy,investigate its dynamic changes under different disease conditions,and explore how autophagy modulation can improve platelet function and treat related diseases.This will provide a theoretical foundation for developing novel therapeutic strategies and is expected to bring breakthroughs in the treatment of platelet-related diseases.关键词
血小板/自噬/免疫性血小板减少症/富血小板血浆Key words
platelets/autophagy/immune thrombocytopenia/platelet-rich plasma分类
医药卫生引用本文复制引用
赵珍玉,贺小艳,肖潇,陈雪梅,唐洁..自噬与血小板:机制、功能及相关疾病研究进展[J].中国输血杂志,2026,39(4):557-563,7.基金项目
绵阳市中心医院孵化课题项目(2022FH005) （2022FH005）
绵阳市中心医院人才引进课题项目(2025RCYJ-005) （2025RCYJ-005）
绵阳市中心医院孵化课题项目(2024FH003) （2024FH003）
