中国比较医学杂志2026，Vol.36Issue(7)：74-85,12.DOI:10.3969/j.issn.1671-7856.2026.07.007
基于铁死亡理论探讨中医药延缓腰椎间盘退变的基础研究
Use of traditional Chinese medicine to delay lumbar intervertebral disc degeneration based on the ferroptosis theory
摘要
Abstract
Ferroptosis is an iron-dependent form of programmed cell death that plays a key role in the pathological process of intervertebral disc degeneration(IVDD).Traditional Chinese medicine,with its advantages in overall conditioning,has demonstrated unique potential in the prevention and treatment of IVDD.This review considers the pathological mechanism of IVDD and its interaction with ferroptosis,revealing ferroptosis as not only a pathological driving factor,but also a therapeutic regulatory target.The theory of ferroptosis has great potential in guiding interventions for IVDD using traditional Chinese medicine.By targeting the key pathways of ferroptosis and exploring the potential mechanisms of ferroptosis-related genes,it provides a new perspective and theoretical basis for the prevention and treatment of IVDD using traditional Chinese medicine,and also lays the foundation for the development of precise treatment strategies.关键词
腰椎间盘退变/铁死亡/氧化应激/铁代谢/自噬/中医药Key words
intervertebral disc degeneration/ferroptosis/oxidative stress/iron metabolism/autophagy/traditional Chinese medicine分类
医药卫生引用本文复制引用
陈超棋,申保鑫,刘飞,杨磊,宋超,黄吴涛,陈锋..基于铁死亡理论探讨中医药延缓腰椎间盘退变的基础研究[J].中国比较医学杂志,2026,36(7):74-85,12.基金项目
国家自然科学基金项目(8236150244) （8236150244）
广西中医药跨学科创新团队项目(GZKJ2310) （GZKJ2310）
广西中医药大学自然科学研究项目(2024QN035) （2024QN035）
2025年度广西高校中青年教师科研基础能力提升项目(2025KY0369). （2025KY0369）
