中国比较医学杂志2026，Vol.36Issue(7)：86-101,16.DOI:10.3969/j.issn.1671-7856.2026.07.008
基于氧化应激探讨中医药干预缺血性脑卒中的研究进展
Research progress in traditional Chinese medicine interventions for ischemic stroke based on oxidative stress
摘要
Abstract
Ischemic stroke(IS)is a cerebrovascular disease with high global mortality.Its occurrence and development are closely related to oxidative stress.Vascular recanalization is mainly used to restore cerebral blood circulation;however,it may also cause cerebral ischemia-reperfusion injury and further aggravate neurological damage.The single-target treatment strategy of modern medicine has certain limitations,making the overall intervention advantages of multicomponent,multichannel,and multi-target traditional Chinese medicine increasingly valued.This paper systematically summarizes research into oxidative stress involved in the pathological process of IS by mediating inflammatory responses,affecting the function of neurovascular units,regulating key signaling pathways,destroying the integrity of the blood-brain barrier,inducing apoptosis,and regulating autophagy.In recent years,extensive research on traditional Chinese medicine monomers and active ingredients has been performed,showing that it has good potential for improving clinical symptoms and neurological function recovery in IS.With an emphasis on oxidative stress,this paper aims to summarize the mechanism of action and clinical research progress of traditional Chinese medicine in IS treatment to provide a theoretical reference and ideas for the clinical prevention and treatment of this disease and the development of new drugs.Follow-up studies should focus on elucidating the mechanism of multicomponent synergistic anti-oxidative stress effects of traditional Chinese medicine,constructing a sequential treatment scheme of integrated traditional Chinese and western medicine,and carrying out high-quality research to establish clinical evidence.This review provides accurate prediction models,timing optimization strategies,and high-level medical evidence for the prevention and treatment of cerebral ischemia-reperfusion injury,promotes the transformation of basic research result into clinical practice,and provides new strategies for IS prevention and treatment.关键词
氧化应激/缺血性脑卒中/中医药/研究进展Key words
oxidative stress/ischemic stroke/traditional Chinese medicine/research progress分类
医药卫生引用本文复制引用
华文龙,李梦醒,乔峰,蒋雨晴,孙梦洁,唐巍..基于氧化应激探讨中医药干预缺血性脑卒中的研究进展[J].中国比较医学杂志,2026,36(7):86-101,16.基金项目
国家自然科学基金项目(82474617,82305361) （82474617,82305361）
安徽省自然科学基金(2308085MH298) （2308085MH298）
安徽省高等学校科学研究项目(2023AH050845) （2023AH050845）
安徽省新时代育人质量工程项目(2024cxcysj130). （2024cxcysj130）
