中国现代医学杂志2026，Vol.36Issue(8)：37-42,6.DOI:10.3969/j.issn.1005-8982.2026.08.007
双歧杆菌乳杆菌三联活菌片联合消旋卡多曲对儿童轮状病毒性腹泻的疗效分析
Efficacy of Bifidobacterium Lactobacillus triple live tablets combined with racecadotril in the treatment of rotavirus diarrhea in children
摘要
Abstract
Objective To investigate the clinical efficacy of Bifidobacterium Lactobacillus triple live tablets combined with racecadotril in children with rotavirus diarrhea.Methods A total of 120 pediatric patients with rotavirus-induced diarrhea admitted to the Chengdu Public Health Clinical Medical Center from June 2022 to June 2025 were selected as the study subjects.Using a simple randomization envelope drawing method,they were randomly divided into a routine group(n=60)and a combination group(n=60).The routine group received standard treatment,while the combination group received additional Bifidobacterium Lactobacillus triple live tablets and racecadotril.Clinical efficacy,symptom improvement,immune indicators[immunoglobulin A(IgA),IgG,IgM],intestinal flora composition,and gastrointestinal hormone[gastrin(GAS),motilin(MOT),and vasoactive intestinal peptide(VIP)]levels were compared between the two groups.Results The overall effective rate was significantly higher in the combination group than in the routine group(P＜0.05).The time to diarrhea cessation,vomiting cessation,fever abatement,and normalization of stool consistency were all shorter in the combination group(P＜0.05).After treatment,the levels of IgA,IgG,and IgM were significantly higher in the combination group than in the routine group(P＜0.05).The differences in IgA,IgG,and IgM levels before and after treatment were greater in the combination group than in the routine group(P＜0.05).After treatment,the content of Enterobacteriaceae was significantly lower in the combination group(P＜0.05),while the contents of Bifidobacterium and Lactobacillus were significantly higher in the combination group compared to the routine group(P＜0.05).The differences in Enterobacteriaceae,Bifidobacterium,and Lactobacillus contents before and after treatment were greater in the combination group than in the routine group(P＜0.05).After treatment,the levels of GAS,MOT,and VIP were significantly lower in the combination group than in the routine group(P＜0.05).The differences in GAS,MOT,and VIP levels before and after treatment were greater in the combination group than in the routine group(P＜0.05).Conclusion Bifidobacterium Lactobacillus triple live tablets combined with racecadotril exert a significant therapeutic effect on rotavirus diarrhea in children.关键词
轮状病毒性腹泻/双歧杆菌乳杆菌三联活菌片/消旋卡多曲/肠道菌群含量Key words
rotavirus diarrhea/Bifidobacterium Lactobacillus triple live tablets/racecadotril/intestinal flora分类
医药卫生引用本文复制引用
许超,余珍燕,刘丹,张阳..双歧杆菌乳杆菌三联活菌片联合消旋卡多曲对儿童轮状病毒性腹泻的疗效分析[J].中国现代医学杂志,2026,36(8):37-42,6.基金项目
四川省科技计划项目(23NSFSC5420) （23NSFSC5420）
