中国现代医学杂志2026，Vol.36Issue(8)：56-63,8.DOI:10.3969/j.issn.1005-8982.2026.08.010
维生素D在自身免疫性疾病中的作用机制研究进展
Research advances on the role of vitamin D in autoimmune diseases
摘要
Abstract
Vitamin D,a fat-soluble steroid hormone,plays a pivotal role not only in maintaining calcium homeostasis but also in stimulating innate immunity and inducing immune tolerance,thereby exerting immunomodulatory and anti-inflammatory effects.Vitamin D deficiency has been implicated in exacerbating inflammatory responses and immune dysregulation in various autoimmune diseases,leading to increased incidence and prolonged progression,and is thus considered closely associated with the pathogenesis of autoimmune disorders.Furthermore,accumulating evidence suggests that adequate supplementation of vitamin D and its analogues demonstrates beneficial preventive and therapeutic effects in certain autoimmune conditions.This review provides a comprehensive summary of the critical roles,underlying mechanisms,and clinical advances of vitamin D in autoimmune regulation,aiming to establish a theoretical foundation for its clinical application in disease management.关键词
自身免疫性疾病/维生素D/免疫调节/炎症/临床应用Key words
autoimmune diseases/vitamin D/immunomodulation/inflammation/clinical application分类
医药卫生引用本文复制引用
杨晶涵,杨茹涵,陈纬纬,孙凌云..维生素D在自身免疫性疾病中的作用机制研究进展[J].中国现代医学杂志,2026,36(8):56-63,8.基金项目
国家自然科学基金重点项目(82330055) （82330055）
