中国现代医学杂志2026，Vol.36Issue(8)：97-102,6.DOI:10.3969/j.issn.1005-8982.2026.08.016
创伤性颅脑损伤患者血清TMAO、Apelin-13水平及Helsinki CT评分与损伤程度的相关性分析
Associations of serum TMAO and Apelin-13 levels and Helsinki CT scores with the disease severity in patients with traumatic brain injury
摘要
Abstract
Objective To explore the serum trimethylamine-N-oxide(TMAO)and Apelin-13 levels and Helsinki CT scores in patients with traumatic brain injury(TBI)and their associations with disease severity,and to assess the potential value of these biomarkers for the prognosis of TBI patients.Methods A total of 129 TBI patients treated at our Hospital from March 2022 to March 2024 were selected for this study.Based on the National Institutes of Health Stroke Scale(NIHSS)scores,patients were divided into severe(n=32),moderate(n=51),and mild(n=46)groups.Serum levels of TMAO and Apelin-13,as well as Helsinki CT scores,were compared among the groups,and their correlations with the severity of the disease were investigated.The value of TMAO,Apelin-13,and Helsinki CT scores in assessing the severity of the disease was evaluated using the receiver operating characteristic(ROC)curve analysis.Results Serum TMAO levels and Helsinki CT scores in the severe and moderate groups were higher than those in the mild group(P＜0.05),and were higher in the severe group than in the moderate group(P＜0.05).Serum Apelin-13 levels in the severe and moderate groups were lower than those in the mild group(P＜0.05),and were lower in the severe group than in the moderate group(P＜0.05).Spearman correlation analysis showed that disease severity was positively correlated with serum TMAO levels(rs=0.612,P=0.000)and Helsinki CT scores(rs=0.707,P=0.000),and negatively correlated with serum Apelin-13 levels(rs=-0.844,P=0.000).The ROC curve analysis revealed that combination of serum TMAO and Apelin-13 levels and Helsinki CT scores yielded the largest area under the curve of 0.987(95％CI:0.974,1.000),with a sensitivity of 95.2％(95％CI:0.792,0.992)and a specificity of 93.5％(95％CI:0.870,0.977).Serum TMAO levels and Helsinki CT scores in the poor-prognosis group were higher than those in the good-prognosis group(P＜0.05),whereas serum Apelin-13 levels were lower in the poor-prognosis group(P＜0.05).Conclusion The serum levels of TMAO and Apelin-13 and Helsinki CT scores are closely related to the disease severity and prognosis of TBI patients,and can serve as effective biomarkers for assessing disease severity and prognosis.关键词
创伤性颅脑损伤/三甲胺-N-氧化物/Apelin-13/Helsinki CT评分/严重程度/预后评估Key words
traumatic brain injury/trimethylamine-N-oxide/Apelin-13/Helsinki CT score/severity/prognosis assessment分类
医药卫生引用本文复制引用
贾攀攀,余德顺,孔浩南..创伤性颅脑损伤患者血清TMAO、Apelin-13水平及Helsinki CT评分与损伤程度的相关性分析[J].中国现代医学杂志,2026,36(8):97-102,6.基金项目
浙江省医药卫生科技计划项目(2023KY248) （2023KY248）
