中国心理卫生杂志2026，Vol.40Issue(5)：377-382,6.DOI:10.3969/j.issn.1000-6729.2026.05.02
精神分裂症患者认知损害与前额叶功能连接的相关性分析
Association between cognitive impairment and prefrontal functional connectivity in patients with schizophrenia
摘要
Abstract
Objective:To examine the characteristics of resting-state functional connectivity(FC)abnormali-ties within the prefrontal cortex(PFC)of individuals diagnosed with schizophrenia(SCZ)and to explore their rela-tionship with cognitive impairment,utilizing functional near-infrared spectroscopy(fNIRS).Methods:Fifty-two pa-tients with schizophrenia and 51age-and sex-matched normal controls were enrolled.The resting-state oxyhemoglo-bin(HbO)signals in the PFC were recorded using fNIRS,and cognitive performance was evaluated using the MA-TRICS Consensus Cognitive Battery(MCCB).Five regions of interest(ROIs),the frontal pole cortex(FPC),or-bitofrontal cortex(OFC),temporal pole cortex(TPC),inferior prefrontal cortex(IPFC),and dorsolateral prefrontal cortex(dPFC)were selected.Analyses were conducted to assess group differences in FC and their correlations with cognitive scores.Results:The scores of cognitive functions in all domains were lower in SCZ group than in the nor-mal control group(Ps＜0.05).The functional connectivity(FC)of the prefrontal cortex(PFC)was reduced in the resting state,and the working memory was positively correlated with the FC intensity between the FPC-dPFC(r=0.35,P＜0.05)and IPFC-dPFC(r=0.44,P＜0.05).Conclusion:Patients with schizophrenia have widespread cognitive impairments,and the decline in working memory may be related to the reduced FC between specific pre-frontal subregions.关键词
精神分裂症/认知损害/功能性近红外脑成像/脑功能连接Key words
schizophrenia/cognitive impairment/functional near infrared spectroscopy/functional connec-tivity分类
医药卫生引用本文复制引用
刘冰倩,储鑫,翟金国,郁昊,薛冉冉,王利峰,季善玲..精神分裂症患者认知损害与前额叶功能连接的相关性分析[J].中国心理卫生杂志,2026,40(5):377-382,6.基金项目
国家自然科学基金面上项目(82471526),国家自然科学基金青年项目(81901358),山东省自然科学基金青年项目(ZR2019BH001),山东省自然科学基金优青项目(ZR2021YQ55),山东省泰山学者青年专家计划(tsqn201909146),山东省自然科学基金青年项目(ZR2024QH652),山东省医药卫生科技项目(202403091165),济宁市重点研发计划(2023YXNS141),山东省大学生科研项目(24SSR028) （82471526）
