中国药科大学学报2026，Vol.57Issue(2)：144-154,11.DOI:10.11665/j.issn.1000-5048.2025122502
链霉菌细胞色素P450酶的功能及改造和应用
Cytochrome P450 enzymes from Streptomyces:functions and engineering approaches for applications
尹莹莹 1陈依军1
作者信息
- 1. 中国药科大学生命科学与技术学院,南京 211198
- 折叠
摘要
Abstract
Cytochrome P450 enzymes represent a class of heme-containing protease widely distributed across the biological kingdom.Endowed with a broad substrate scope,diverse catalytic reaction profiles,high regio-and stereoselectivity toward substrates,and mild catalytic conditions,these enzymes stand out as superior biocatalysts with good potential of application.As one of the primary producers of natural products,Streptomyces harbors a wealth of P450 enzymes and natural product biosynthetic gene clusters(BGCs)in its genome,making it a versatile treasure trove for the generation of bioactive small-molecule compounds.This review summarizes the catalytic reactions by Streptomyces-derived P450 enzymes in natural product biosynthesis and delineates the engineering strategies for addressing the practical application challenges of P450 enzymes,aiming to provide some reference and guidance for in-depth research on P450 enzymes and their applications.关键词
细胞色素P450酶/链霉菌/天然产物/生物合成/工业化应用Key words
cytochrome P450 enzymes/Streptomyces/natural products/biosynthesis/industrial application分类
生物科学引用本文复制引用
尹莹莹,陈依军..链霉菌细胞色素P450酶的功能及改造和应用[J].中国药科大学学报,2026,57(2):144-154,11.
