中国药科大学学报2026，Vol.57Issue(2)：172-180,9.DOI:10.11665/j.issn.1000-5048.2025090901
中药皮肤药代动力学评价技术研究进展
Advances in evaluation techniques for traditional Chinese medicine dermatopharmacokinetics
摘要
Abstract
Evaluating the absorption of traditional Chinese medicine(TCM)formulations in skin has long been a challenge in cutaneous pharmacokinetic studies of TCM.In recent years,various new techniques,including diffusion cell,microphysiological system,matrix-assisted laser desorption/ionization mass spectrometry imaging,tape stripping,microdialysis/open-flow microperfusion,and confocal Raman microscopy technology,have been developed to characterize and predict the pharmacokinetic profiles of these formulations more accurately.This review systematically summarizes the application progress of these methods in the evaluation of cutaneous pharmacokinetics of TCM,highlights their technical features and suitable scenarios,and discusses future development trends,providing new research perspectives for further understanding the dynamic changes,spatial distribution characteristics of active ingredients in the skin,and the rationality of compatibility in topical preparations.关键词
中药皮肤药代动力学/胶带剥离/微透析/开放式微灌流/共聚焦拉曼显微镜/基质辅助激光解吸/电离质谱成像Key words
traditional Chinese medicine dermatopharmacokinetics/tape stripping/microdialysis/open flow microperfusion/confocal Raman microscopy/matrix-assisted laser desorption/ionization mass spectrometry imaging分类
医药卫生引用本文复制引用
陈仪巧,孙露,闻晓东..中药皮肤药代动力学评价技术研究进展[J].中国药科大学学报,2026,57(2):172-180,9.基金项目
国家重点研发计划项目(2018YFC1704503) （2018YFC1704503）
中国药科大学附属江宁中医院科研项目(YJZD2025008)This study was supported by the National Key Research and Development Program of China(2018YFC1704503) （YJZD2025008）
the Scientific Research Project of Jiangning Hospital Affiliated to China Pharmaceutical University(YJZD2025008) （YJZD2025008）
