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胃肠外直接凝血酶抑制剂在特殊人群中的临床应用专家共识

姚芯李芹胡宝荣边原韩丽珠尹琪楠雷洋万子梦黄璐瑶赵丹洁严郁

中国药房2026，Vol.37Issue(8)：965-975,11.

中国药房2026，Vol.37Issue(8)：965-975,11.DOI:10.6039/j.issn.1001-0408.2026.08.01

胃肠外直接凝血酶抑制剂在特殊人群中的临床应用专家共识

Expert consensus on the clinical application of parenteral direct thrombin inhibitors in special populations

姚芯 ¹李芹 ²胡宝荣 ³边原 ⁴韩丽珠 ⁵尹琪楠 ⁵雷洋 ⁵万子梦 ⁶黄璐瑶 ⁷赵丹洁 ⁸严郁⁹

作者信息

1. 四川省医学科学院·四川省人民医院(电子科技大学附属医院)药学部/个体化药物研究与治疗四川省重点实验室,成都 610072||电子科技大学医学院,成都 610054
2. 西南医科大学附属医院药学部,四川泸州 646000
3. 哈尔滨医科大学附属第一医院药学部,哈尔滨 150001
4. 四川省医学科学院·四川省人民医院(电子科技大学附属医院)药学部/个体化药物研究与治疗四川省重点实验室,成都 610072||四川大学华西医院生物治疗全国重点实验室,成都 610041
5. 四川省医学科学院·四川省人民医院(电子科技大学附属医院)药学部/个体化药物研究与治疗四川省重点实验室,成都 610072
6. 岳阳市中心医院药学部,湖南岳阳 414000
7. 西藏自治区人民政府驻成都办事处医院药剂科,成都 610041
8. 成都市双流区第一人民医院(四川大学华西空港医院)药学部,成都 610200
9. 四川大学华西医院药剂科,成都 610041
折叠

摘要

Abstract

OBJECTIVE To form an expert consensus addressing clinical issues regarding the use of parenteral direct thrombin inhibitors (DTIs) in special populations.METHODS Led by the Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital(the Affiliated Hospital of UESTC),a multidisciplinary working group was formed comprising experts from multiple fields,including clinical pharmacy,cardiac surgery,obstetrics,pediatrics and evidence-based medicine.Through literature review and the Delphi method,clinical questions regarding the efficacy and safety of parenteral DTIs used in special populations were identified.A structured design was adopted using the"Population-Intervention-Comparison-Outcome"(PICO)framework;systematic searches were conducted in CJFD,PubMed,Embase and other databases.Relevant evidence from randomized controlled trials,cohort studies and systematic reviews were included and synthesized.Evidence quality was assessed using the Grading of Recommendations Assessment,Development and Evaluation(GRADE)approach,and recommendations were formulated through three rounds of Delphi surveys and expert consensus meetings.RESULTS&CONCLUSIONS Seven clinical questions were ultimately selected(with a consensus rate exceeding 90％),resulting in the formulation of seven recommendations on the use of parenteral DTIs in special populations,including children,pregnant women,patients with hepatic or renal impairment,patients with mesenteric venous thrombosis,and individuals with thrombophilia.These recommendations clarify the preferred agents,dosing ranges,monitoring parameters,and safety management strategies for parenteral DTIs in these special populations.This expert consensus,which is formulated based on the best available evidence,provides evidence-based guidance for standardized and individualized use of parenteral DTIs in special populations.

关键词

胃肠外直接凝血酶抑制剂/特殊人群/血栓栓塞/抗凝治疗/止血策略/专家共识

Key words

parenteral direct thrombin inhibitors/special populations/thromboembolism/anticoagulation therapy/hemostatic strategies/expert consensus

分类

医药卫生

引用本文复制引用

姚芯,李芹,胡宝荣,边原,韩丽珠,尹琪楠,雷洋,万子梦,黄璐瑶,赵丹洁,严郁..胃肠外直接凝血酶抑制剂在特殊人群中的临床应用专家共识[J].中国药房,2026,37(8):965-975,11.

基金项目

四川省自然科学基金(No.2022NSFSC0818) （No.2022NSFSC0818）

四川省药品监督管理局药品科技计划项目(No.2024012) （No.2024012）

中国药房

ISSN：1001-0408

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