中国药房2026，Vol.37Issue(8)：1092-1098,7.DOI:10.6039/j.issn.1001-0408.2026.08.21
天然活性成分通过HIF-1α干预椎间盘退变"缺氧-焦亡-炎症"级联反应的研究进展
Research progress on natural active ingredients intervening in the hypoxia-pyroptosis-inflammation cascade in intervertebral disc degeneration through HIF-1α
摘要
Abstract
Intervertebral disc degeneration(IVDD)is the core cause of chronic low back pain,which severely impairs patients'quality of life and imposes a heavy social and medical burden.The hypoxia-pyroptosis-inflammation cascade mediated by hypoxia-inducible factor-1α(HIF-1α)is the core pathological mechanism driving the initiation and progression of IVDD.Natural active ingredients derived from traditional Chinese medicine(TCM)have become a research hotspot in the field of IVDD prevention and treatment due to their advantages of multi-target effects,favorable efficacy,and low toxicity.This paper systematically reviews the mechanism of HIF-1α-mediated hypoxia-pyroptosis-inflammation cascade in degenerative nucleus pulposus tissue and the intervention of related active ingredients.It is found that natural active ingredients such as baicalein,curcumin and resveratrol can intervene in the HIF-1α-mediated pathological cascade through four core links to delay IVDD progression:targeting the HIF-1α oxygen sensing pathway to block the initiation of pyroptosis cascade,inhibiting NOD-like receptor protein 3 inflammasome activation to cut off the cascade amplification of inflammatory signals,intervening in the Gasdermin D-mediated pyroptosis execution stage to protect cell membrane integrity,and regulating extracellular matrix metabolism to reconstruct intervertebral disc homeostasis.关键词
缺氧诱导因子1α/天然活性成分/髓核组织/缺氧/焦亡/炎症Key words
HIF-1α/natural active ingredients/nucleus pulposus tissue/hypoxia/pyroptosis/inflammation分类
医药卫生引用本文复制引用
王浩,陈仁场,黄文浩,周冰倩,郑喜秋,王佳浩,李念虎,吴亚东..天然活性成分通过HIF-1α干预椎间盘退变"缺氧-焦亡-炎症"级联反应的研究进展[J].中国药房,2026,37(8):1092-1098,7.基金项目
山东省自然科学基金项目(No.ZR2021LZY006,No.ZR2023MH063) （No.ZR2021LZY006,No.ZR2023MH063）
