中国医科大学学报2026，Vol.55Issue(4)：354-358,5.DOI:10.12007/j.issn.0258-4646.2026.04.011
血清lncRNA SNHG14和miR-150-5p水平对重症肺炎患者预后的预测价值
Predictive value of serum lncRNA SNHG14 and miR-150-5p levels for the prognosis of patients with severe pneumonia
摘要
Abstract
Objective To evaluate the predictive value of serum long non-coding RNA(lncRNA)SNHG14 and microRNA(miR)-150-5p for the prognosis of patients with severe pneumonia.Methods This observational cohort study included 125 patients with severe pneumonia who were admitted to our hospital between June 2022 and January 2025.The patients were classified into two groups based on their 28-day prognosis as the death group(n=53)and the survival group(n=72).Real-time quantitative PCR(qRT-PCR)technology was used to measure serum lncRNA SNHG14 and miR-150-5p levels in patients upon admission.Baseline clinical data of enrolled patients were also collected.Cox regression was employed to identify factors influencing the prognosis of patients with severe pneumonia.Receiver operating characteristic(ROC)curves were constructed to evaluate the predictive value of serum lncRNA SNHG14 and miR-150-5p in the prognosis of patients with severe pneumonia.Pearson's method was used to analyze the correlation between serum lncRNA SNHG14 and miR-150-5p.Results The death group had significantly higher serum lncRNA SNHG14 levels,a higher Sequential Organ Failure Assessment(SOFA)score,Acute Physiology And Chronic Health EvaluationⅡ(APACHEⅡ)score,proportion of invasive mechanical ventilation,and conspicuously lower serum miR-150-5p levels than the survival group(P<0.05).The multivariate Cox regression indi-cated that the mechanical ventilation mode,SOFA score,APACHEⅡscore,lncRNA SNHG14,and miR-150-5p were all factors influ-encing the prognosis of patients with severe pneumonia(P<0.05).The area under the curve(AUC)values of serum lncRNA SNHG14,miR-150-5p,and their combination for predicting the prognosis of severe pneumonia were 0.780,0.810,and 0.876,respectively.The com-bination group had significantly higher predictive power than the single indicator group(ZlncRNA SNHG14=2.836,P=0.005;ZmiR-150-5p=2.130,P=0.033).The serum lncRNA SNHG14 levels in patients with severe pneumonia were negatively correlated with miR-150-5p(r=-0.418,P<0.05),indicating a potential targeted binding site between the two.Conclusion Serum lncRNA SNHG14 was highly expressed,and miR-150-5p was expressed at low levels in patients with severe pneumonia.Therefore,the combined detection of these two can provide an effective reference for predicting the prognosis of patients with severe pneumonia.关键词
长链非编码RNA SNHG14/miR-150-5p/重症肺炎/预后Key words
long non-coding RNA SNHG14/miR-150-5p/severe pneumonia/prognosis分类
医药卫生引用本文复制引用
刘虹,拉周措毛,李国蓉,刘洪千..血清lncRNA SNHG14和miR-150-5p水平对重症肺炎患者预后的预测价值[J].中国医科大学学报,2026,55(4):354-358,5.基金项目
青海省科技计划项目(2022-ZJ-775) （2022-ZJ-775）
