中国医科大学学报2026，Vol.55Issue(4)：372-376,5.DOI:10.12007/j.issn.0258-4646.2026.04.014
NLRP3炎症小体在特应性皮炎中的调控机制及治疗应用
Regulatory mechanism and therapeutic application of NLRP3 inflammasome in atopic dermatitis
摘要
Abstract
Atopic dermatitis(AD)is a chronic inflammatory skin disease caused by genetic,immunological and environmental factors,with persistent and recurrent characteristics.Nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome promotes the maturation of inflammatory factors interleukin(IL)-1β and IL-18 through the activation of various stimuli,and then regulate the helper-T lymphocytes(Th)2/Th1 immune shift,which plays a key role in the pathogenesis of atopic dermatitis in acute and chronic phases.Inhibition of its activation can significantly alleviate symptoms of AD.This review systematically summarizes the research progress in the pathogenesis and therapeutic applications of the NLRP3 inflammasome in AD,which provides a theoretical basis for the application of inhibitors targeting this inflammasome for the treatment of atopic dermatitis.关键词
特应性皮炎/炎症小体/核苷酸结合寡聚化结构域样受体蛋白3/抑制剂Key words
atopic dermatitis/inflammasome/nucleotide-binding oligomerization domain-like receptor protein 3/inhibitor分类
医药卫生引用本文复制引用
梁书宁,金珊..NLRP3炎症小体在特应性皮炎中的调控机制及治疗应用[J].中国医科大学学报,2026,55(4):372-376,5.基金项目
国家自然科学基金(82060573) （82060573）
