摘要
Abstract
Spinal cord injury(SCI)is a severe traumatic disease of the central nervous system.Its complex pathophysiological processes,especially secondary injury,pose a major challenge to clinical treatment.Ferroptosis,a form of programmed cell death characterized by iron-dependent lipid peroxida-tion,has been recognized as an important mechanism in secondary spinal cord injury.Hypoxia-induc-ible factor-1α(HIF-1α),a key transcription factor involved in the cellular response to hypoxia,regulates iron metabolism,oxidative stress,and inflammatory signaling pathways,thereby influencing the pro-gression of SCI and neurological recovery.This review summarizes the pathophysiological processes of SCI,mechanisms of ferroptosis,and regulatory roles of HIF-1α.In addition,the potential involvement of HIF-1α in ferroptosis after SCI is explored in order to offer new lines of thought for potential therapeu-tic strategies.关键词
脊髓损伤/铁死亡/低氧诱导因子1α/氧化应激/铁代谢/继发性损伤Key words
spinal cord injury/ferroptosis/hypoxia-inducible factor-1α/oxidative stress/iron metabolism/secondary injury分类
医药卫生
