中国医学工程2026，Vol.34Issue(3)：19-25,7.DOI:10.19338/j.issn.1672-2019.2026.03.003
基于磁共振多模态功能成像的静脉源性脑微出血小鼠影像表征研究
Imaging characterization of venous origin CMBs in mice based on high field MR multimodal functional imaging
摘要
Abstract
[Objective]Cerebral microbleeds(CMBs)are insidious in onset and have a complex mechanism of occurrence.Therefore,this study aims to explore whether there is a causal relationship between them and CMBs by preparing models of venous circulation disorders at different positions,and to evaluate the detection efficiency of different MRI functional sequences for venous CMBs.[Methods]Twenty C57BL/6J mice were selected,and the internal and external jugular veins were selectively ligated to prepare four groups of mouse models of cerebral venous circulation disorders at different locations(n=5),namely the bilateral internal and external jugular vein ligation(JVL),bilateral external jugular vein ligation(EJV),bilateral internal jugular vein ligation(IJV),and control groups.Subsequently,MRI multimodal functional imaging,and pathological HE staining were carried out for comprehensive evaluation.[Results]Magnetic resonance multimodal functional imaging showed that CMBs appeared in the SWI sequence in the JVL group of mice,and there were no abnormalities in the brains of mice in the other groups.According to the pathological results,CMBs occurred in both the bilateral IJV group and the JVL group of mice,and the number and area of CMBs in the latter were larger(P<0.05).Spearman correlation analysis showed that the number of CMBs in a single slice(r=0.82,P<0.01)and the area of CMBs(r=0.97,P<0.001)were positively correlated with the number of CMBs detected by SWI.[Conclusion]Cerebral venous circulation disorders can lead to the occurrence of CMBs,and circulation disorders in different parts have different pathogenicity for CMBs.For venous origin CMBs,susceptibility weighted imaging has higher sensitivity compared with T1WI,T2WI,and DWI imaging methods.关键词
脑微出血/MRI多模态功能成像/静脉循环障碍Key words
cerebral microbleeds/MR multimodal functional imaging/venous circulation disorder分类
医药卫生引用本文复制引用
张萌萌,周欣,李绎达,郭靖,盖雪,金毅,李国华..基于磁共振多模态功能成像的静脉源性脑微出血小鼠影像表征研究[J].中国医学工程,2026,34(3):19-25,7.基金项目
齐齐哈尔市科技局联合引导项目(LSFGG-2022067) （LSFGG-2022067）
齐齐哈尔医学院研究生创新基金项目(QYYCX2022-16) （QYYCX2022-16）
