中国针灸2026，Vol.46Issue(4)：517-522,6.DOI:10.13703/j.0255-2930.20250301-k0001
改良无痛麦粒化脓灸对风寒袭肺型咳嗽变异性哮喘的影响:随机对照试验
Effect of modified painless wheat-grain blistering moxibustion on cough variant asthma of wind cold attacking the lung:a randomized controlled trial
摘要
Abstract
Objective To observe the clinical efficacy of modified painless wheat-grain blistering moxibustion combined with western medication for cough variant asthma(CVA)of wind cold attacking the lung.Methods Ninety-four patients with CVA of wind cold attacking the lung were randomly divided into a wheat-grain blistering moxibustion group and a montelukast sodium group,47 cases in each group.The montelukast sodium group was treated with oral montelukast sodium tablets,10 mg each time,once a day for 8 weeks.The wheat-grain blistering moxibustion group was treated with modified painless wheat-grain blistering moxibustion at Dingchuan(EX-B1),Fengmen(BL12),Gaohuang(BL43)and Zusanli(ST36)on the basis of the treatment in the montelukast sodium group,the acupoints on both sides were selected alternately for moxibustion,once every other day,three times a week for 8 weeks.The TCM syndrome score before and after treatment,as well as after 1 month of treatment completion(follow-up)was observed,the pulmonary function indexes(forced expiratory volume in 1 second[FEV1],peak expiratory flow[PEF]and FEV1/forced vital capacity[FVC]%),and serum levels of immunoglobulin E(IgE)and interleukin-6(IL-6)were detected before and after treatment,the clinical efficacy was evaluated in the two groups.Results After treatment and in follow-up,the TCM syndrome scores in both groups were decreased compared with those before treatment(P＜0.05),and the scores in the wheat-grain blistering moxibustion group were lower than those in the montelukast sodium group(P＜0.01).After treatment,the FEV1,PEF and FEV1/FVC%were increased compared with those before treatment(P＜0.05),while serum levels of IgE and IL-6 were decreased compared with those before treatment(P＜0.05)in both groups;the FEV1,PEF and FEV1/FVC%in the wheat-grain blistering moxibustion group were higher than those in the montelukast sodium group(P＜0.01,P＜0.05),the serum levels of IgE and IL-6 in the wheat-grain blistering moxibustion group were lower than those in the montelukast sodium group(P＜0.01).After treatment,the total effective rate was 100.0%(47/47)in the wheat-grain blistering moxibustion group and 93.6%(44/47)in the montelukast sodium group,with no statistically significant difference between the two groups(P＞0.05).In follow-up,the total effective rate was 95.7%(45/47)in the wheat-grain blistering moxibustion group and 42.6%(20/47)in the montelukast sodium group,total effective rate in the wheat-grain blistering moxibustion group was superior to that in the montelukast sodium group(P＜0.01).Conclusion Modified painless wheat-grain blistering moxibustion combined with montelukast sodium tablets can alleviate cough symptoms and improve lung function in patients with CVA of wind cold attacking the lung.Its mechanism may be related to regulating the serum levels of IgE and IL-6,thereby inhibiting airway inflammatory responses.关键词
咳嗽变异性哮喘/风寒袭肺/改良无痛麦粒化脓灸/肺功能/随机对照试验Key words
cough variant asthma/wind cold attacking the lung/modified painless wheat-grain blistering moxibustion/lung function/randomized controlled trial(RCT)引用本文复制引用
李俊材,刘越齐,邵智愚,朱海亮,苏秀贞,倪婕,刘佳琳,陈卓..改良无痛麦粒化脓灸对风寒袭肺型咳嗽变异性哮喘的影响:随机对照试验[J].中国针灸,2026,46(4):517-522,6.基金项目
山东省中医药管理局齐鲁医派中医药特色技术推广项目:鲁卫函[2020]132 号 （）
山东省中医药科技项目:Z-2023099T （）
