中国针灸2026，Vol.46Issue(4)：631-638,8.DOI:10.13703/j.0255-2930.20250916-k0001
从"自主神经-免疫"调控解析针刺改善炎症性肠病机制的研究思路探讨
Approaches to the mechanism research of acupuncture for attenuating inflammatory bowel disease from the perspective of"autonomic nerve-immune"regulation
摘要
Abstract
As a kind of physical intervention on the body surface,acupuncture may regulate the activities of autonomic nerve including sympathetic nerve and vagus nerve,and influence the release of many kinds of neurotransmitters,so as to regulate the dynamic,metabolic and immune functions of the effector organs.In recent years,the regulatory role of the nervous system in the pathogenesis and progression of inflammatory bowel disease(IBD)has garnered increasing attention.Although high-quality evidence has revealed the potential of acupuncture to ameliorate systemic inflammation through"nerve-immune"modulation,the research of the"autonomic nerve-immune"mechanism of acupuncture remains limited for attenuating the regional inflammatory responses in IBD.Based on the latest advancements in neuroscience and immunology,this study systematically reviews the nerve-immune regulatory mechanisms underlying IBD and discusses in-depth the potential autonomic nerve-immune regulatory mechanisms of acupuncture in combination with current neurobiological evidence of its anti-inflammatory effect.It suggests adopting systems biology and integrating multidisciplinary technologies to elucidate the"full-chain"evidence of the"acupoint-autonomic nervous system-intestinal immune"regulatory mechanism,and provides the reference for subsequent mechanistic analysis of acupuncture in alleviating IBD.关键词
炎症性肠病/针刺/神经免疫调控/自主神经系统/抗炎机制Key words
inflammatory bowel disease(IBD)/acupuncture/neuro-immune regulation/autonomic nervous system/anti-inflammatory mechanism引用本文复制引用
骆敏,刘筱羽,曲正阳,宿杨帅,景向红..从"自主神经-免疫"调控解析针刺改善炎症性肠病机制的研究思路探讨[J].中国针灸,2026,46(4):631-638,8.基金项目
国家自然科学基金资助项目:82274245、82105033 （）
中国中医科学院优秀青年科技人才(创新类)培养专项:ZZ13-YQ-069 （创新类）
