中国中医基础医学杂志2026，Vol.32Issue(4)：874-881,8.
晚期非小细胞肺癌患者外周血DCreg表达意义及与中医辨证虚实属性差异性研究
Significance of DCreg Expression in Peripheral Blood of Patients with Advanced Non-Small Cell Lung Cancer and Its Differences in the Deficiency and Excess Attributes of Traditional Chinese Medicine Syndrome Differentiation
摘要
Abstract
Objective To detect the expression level of regulatory dendritic cells(DCreg)in the peripheral blood of patients with advanced non-small cell lung cancer(NSCLC)and to explore the clinical value of DCreg in assessing patient condition and deficiency-excess syndrome differentiation.Methods Fifty patients with advanced NSCLC were enrolled as the experimental group,and 10 healthy individuals were included as the control group.Flow cytometry was used to measure DCreg levels in the peripheral blood of both groups.Differences in DCreg levels between NSCLC patients and healthy controls were compared,as well as among NSCLC patient subgroups with different clinical characteristics.Correlations between DCreg levels and T cell subsets,as well as serum cytokines,were analyzed.In addition,differences in DCreg levels among different deficiency-excess syndrome types were compared,and multinomial logistic regression analysis was used to identify the optimal combination of indicators for predicting deficiency and excess syndromes in NSCLC patients.Results DCreg levels in the peripheral blood of NSCLC patients were significantly higher than those in healthy controls(P<0.01).DCreg levels showed correlations with smoking history,clinical stage,Ki-67,Karnofsky score,CD3+T cells,regulatory T cells(Treg),interleukin(IL)-2,interferon(IFN)-γ,IL-4,and IL-10.DCreg levels in the deficiency syndrome group were significantly higher than those in the excess syndrome group(P<0.01).DCreg levels in the mixed deficiency-excess syndrome group were higher than those in the excess syndrome group(P<0.05).Compared with excess syndrome,patients with high DCreg levels,high Treg levels,and a Karnofsky score<80 were more likely to be classified as having deficiency syndrome.Conclusion DCreg may serve as a potential biomarker for evaluating the condition of NSCLC patients.The detection of DCreg provides valuable reference for identifying deficiency and excess syndromes in TCM,though comprehensive assessment incorporating indicators such as Treg levels and Karnofsky score is recommended for clinical application.关键词
非小细胞肺癌/调节性树突状细胞/免疫功能/辨证论治/虚证/实证Key words
Non-small cell lung cancer/Regulatory dendritic cells/Immune function/Syndrome differentiation and treatment/Deficiency syndrome/Excess syndrome分类
医药卫生引用本文复制引用
熊宏泰,马苏苏,宋英,蔡柳,郑红刚..晚期非小细胞肺癌患者外周血DCreg表达意义及与中医辨证虚实属性差异性研究[J].中国中医基础医学杂志,2026,32(4):874-881,8.基金项目
国家自然科学基金面上项目(82174463) （82174463）
中央高水平中医医院临床研究和成果转化能力提升项目(HLCMHPP2023085) （HLCMHPP2023085）
