中国中医药科技2026，Vol.33Issue(2)：121-125,5.
金石清瘟解毒口服液解热镇痛、止咳和化痰平喘药效学实验研究
Pharmacodynamic Study on Antipyretic,Analgesic,Antitussive,Expectorant and Antiasthmatic Effects of Jinshi Qingwen Jiedu Oral Liquid(金石清瘟解毒口服液)
摘要
Abstract
Objective:To investigate the antipyretic,analgesic,antitussive,expectorant,and anti-asthmatic effects of Jinshi Qingwen Jiedu Oral Liquid.Methods:The antipyretic effect was evaluated using a rat fever model induced by 2,4-dinitrophenol.The analgesic effect was assessed via the hot plate test and acetic acid-induced writhing test in mice.The antitussive effect was observed using an ammonia water-induced cough model in mice.The expectorant effect was studied by measuring phenol red secretion in the tracheal segment of mice.The anti-asthmatic effect was examined using an acetylcholine-induced asthma model in guinea pigs.Results:Jinshi Qingwen Jiedu Oral Liquid significantly reduced body temperature in febrile rats,demonstrating an antipyretic effect.It prolonged the pain threshold in the hot plate test and reduced the number of writhes induced by acetic acid,indicating an analgesic effect.The preparation extended the cough latency and reduced cough frequency,confirming its antitussive property.It increased phenol red secretion in the trachea,revealing an expectorant effect.Additionally,it prolonged the asthma induction latency,demonstrating an anti-asthmatic effect.Conclusion:Jinshi Qingwen Jiedu Oral Liquid exhibits antipyretic,analgesic,antitussive,expectorant,and anti-asthmatic properties.关键词
金石清瘟解毒口服液/解热镇痛/止咳/化痰平喘/药效学Key words
Jinshi Qingwen jiedu oral liquid/antipyretic and analgesic/cough suppressant/phlegm removal and asthma relief/pharmacodynamics引用本文复制引用
宋亚娟,任晓蕾,李强..金石清瘟解毒口服液解热镇痛、止咳和化痰平喘药效学实验研究[J].中国中医药科技,2026,33(2):121-125,5.基金项目
黑龙江省中医药管理局中医药科研课题项目(ZHY2024-160) （ZHY2024-160）
黑龙江省自然科学基金项目(LH2024H061) （LH2024H061）
