摘要
Abstract
Objective:To explore the efficacy and safety of Honghe Fujie Lotion combined with fluconazole capsules and lacidophilin vaginal capsules in the treatment of vulvovaginal candidiasis.Methods:A total of 116 patients with vulvovaginal candidiasis admitted to our hospital from June 2022 to May 2024 were selected and divided into the control group and the observation group by random number table method.One case was excluded from the control group due to poor compliance,and 2 cases due to active withdrawal(finally n=55);3 cases were excluded from the observation group due to poor compliance,and 1 case due to incomplete examination and treatment(finally n=54).The control group was treated with fluconazole capsules and lacidophilin vaginal capsules,while the observation group was additionally given Honghe Fujie Lotion on the basis of the control group's treatment.Both groups received continuous medication for 7 days.Vaginal microecological indicators(positive rates of sialidase,leukocyte esterase and catalase),vaginal pH,inflammatory indicators[interleukin-2(IL-2),interleukin-13(IL-13),tumor necrosis factor-α(TNF-α),monocyte chemoattractant protein-1(MCP-1)],vulvovaginal candidiasis symptom scores,recurrence and adverse reactions were compared between the two groups.Results:After treatment,the positive rates of sialidase,leukocyte esterase and catalase decreased in both groups,with no statistically significant difference between the two groups(P>0.05).The vaginal pH,levels of IL-13,TNF-α and MCP-1 decreased in both groups,and the observation group had lower values than the control group(P<0.05);the IL-2 level increased in both groups,and the observation group had a higher level than the control group(P<0.05).Scores of itching,pain,congestion/edema,scratch/erosion/chapping,discharge volume,and total vulvovaginal candidiasis score decreased in both groups,and the observation group had lower scores than the control group(P<0.05).The 6-month recurrence rate after treatment in the observation group(5.56%)was lower than that of the control group(18.18%,P<0.05).There were no statistically significant difference in the 3-month recurrence rate after treatment and total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Honghe Fujie Lotion combined with fluconazole capsules and lacidophilin vaginal capsules can effectively improve vaginal microecology,alleviate symptoms,regulate inflammatory indicator levels,and reduce the recurrence rate in the treatment of vulvovaginal candidiasis.关键词
红核妇洁洗液/氟康唑胶囊/乳酸菌阴道胶囊/霉菌性阴道炎/阴道微生态/复发Key words
Honghe Fujie Lotion/fluconazole capsules/lacidophilin vaginal capsules/vulvovaginal candidiasis/vaginal microecology/recurrence分类
医药卫生
