中国合理用药探索2026，Vol.23Issue(3)：127-134,8.DOI:10.3969/j.issn.2096-3327.2026.03.018
自拟参芪养心汤联合沙库巴曲缬沙坦钠治疗心脾阳虚证冠心病伴心力衰竭的效果观察
Clinical Effect Observation of Self-Designed Shenqi Yangxin Decoction Combined with Sacubitril/Valsartan Sodium in the Treatment of Coronary Heart Disease Complicated with Heart Failure with Heart-Spleen Yang Deficiency Syndrome
摘要
Abstract
Objective:To explore the clinical effect of self-designed Shenqi Yangxin Decoction combined with sacubitril/valsartan sodium in patients with coronary heart disease with heart failure(CHD-HF)of heart-spleen yang deficiency syndrome.Methods:A total of 108 patients with CHD-HF of heart-spleen yang deficiency syndrome diagnosed in our hospital from January 2022 to June 2023 were selected as study subjects.They were divided into the control group and the combined group by random number table method,with 54 patients in each group.Both groups received conventional treatment.The control group was treated with sacubitril/valsartan sodium tablets,while the combined group was additionally given self-designed Shenqi Yangxin Decoction on the basis of the control group's treatment.Clinical efficacy,cardiac function indicators[left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)],inflammatory indicators[C reactive protein(CRP),adiponectin(ADPN),matrix metalloproteinase-9(MMP-9)],myocardial injury indicators[creatine kinase(CK),creatine kinase isoenzyme(CK-MB),cardiac troponin I(cTnI),N-terminal pro-brain natriuretic peptide(NT-proBNP)],vascular endothelial factors[endothelin(ET),calcitonin gene-related peptide(CGRP),nitric oxide(NO)],exercise endurance[6-minute walking distance(6MWD)],quality of life scores[Physical Component Summary(PCS)score,Mental Component Summary(MCS)score],and incidence of adverse reactions were compared between the two groups.Results:After treatment,the total clinical effective rate of the combined group(87.04%)was higher than that of the control group(70.37%,P<0.05).LVEF,ADPN,CGRP,NO,6MWD,PCS score and MCS score increased in both groups,and the combined group had significantly higher values than the control group(P<0.05);LVEDD,LVESD,CRP,MMP-9,CK,CK-MB,cTnI,NT-proBNP and ET decreased in both groups,and the combined group had significantly lower values than the control group(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Self-designed Shenqi Yangxin Decoction combined with sacubitril/valsartan sodium can effectively improve clinical efficacy and cardiac function,reduce the degree of myocardial injury and inflammatory response,optimize the level of vascular endothelial factors,and enhance exercise endurance and quality of life in patients with CHD-HF of heart-spleen yang deficiency syndrome.关键词
自拟参芪养心汤/沙库巴曲缬沙坦钠/冠心病伴心力衰竭/心脾阳虚证/临床效果/心功能Key words
self-designed Shenqi Yangxin Decoction/sacubitril/valsartan sodium/coronary heart disease complicated with heart failure/heart-spleen yang deficiency syndrome/clinical efficacy/cardiac function分类
医药卫生引用本文复制引用
杨琼琼,仲豪杰,陈鑫..自拟参芪养心汤联合沙库巴曲缬沙坦钠治疗心脾阳虚证冠心病伴心力衰竭的效果观察[J].中国合理用药探索,2026,23(3):127-134,8.基金项目
河南省医学科技攻关计划联合共建项目(LHGJ20200979) （LHGJ20200979）
