中国中药杂志2026，Vol.51Issue(7)：1843-1850,8.DOI:10.19540/j.cnki.cjcmm.20251205.401
组学技术在半夏质量评价与药理作用机制研究中的应用
Application of omics in quality evaluation and pharmacological mechanism of Pinellia ternata
摘要
Abstract
As an important component of systems biology,omics technologies,with their advantages of high-throughput and holistic analysis,are profoundly transforming the research model of TCM.Pinellia ternata,a commonly used TCM with the effects of drying dampness and resolving phlegm,directing rebellious Qi downward to stop vomiting,and relieving stuffiness and dissipating binds,presents major challenges in quality control and in the elucidation of its complex pharmacological mechanisms.This article systematically reviews the application progress of omics technologies such as genomics,transcriptomics,proteomics,and metabolomics in the study of P.ternata's quality evaluation(covering factors such as cultivation environment,germplasm resources,and processing)and pharmacological mechanisms(including antiemetic effects,phlegm resolution and asthma relief,treatment of gastrointestinal diseases,and antitumor activities).By sorting through existing research findings,it summarizes the great potential of omics technologies in revealing the pharmacodynamic material basis,quality formation mechanisms,and multi-target action networks of P.ternata,and further looks ahead to future research directions such as multi-omics integration,data mining,and artificial intelligence,with a view to providing systematic theoretical and methodological references for the modernization and internationalization of P.ternata research.关键词
组学技术/半夏/质量评价/药理作用机制Key words
omics technology/Pinellia ternata/quality evaluation/pharmacological mechanism引用本文复制引用
刘源,郭大权,郭威成,张兴俊,陈红刚,杜弢,徐圆圆,齐玉娟,孙逊,权文越,贾袭伟,曾翠云,王惠珍,高素芳..组学技术在半夏质量评价与药理作用机制研究中的应用[J].中国中药杂志,2026,51(7):1843-1850,8.基金项目
国家中药材产业技术体系建设专项(CARS-21) （CARS-21）
甘肃省科技计划项目(21YF5NA130,22CX8NA069) （21YF5NA130,22CX8NA069）
宁夏自然科学基金项目(2024AAC03354) （2024AAC03354）
