中国中药杂志2026，Vol.51Issue(8)：2173-2183,11.DOI:10.19540/j.cnki.cjcmm.20260108.305
中药粉末直接压片技术的前沿拓展:辅料改性及粒子设计与连续制造的整合
Frontiers in direct compression technology for traditional Chinese medicine powder:integration of excipient modification,particle design,and continuous manufacturing
摘要
Abstract
Direct compression(DC)technology has been successfully applied in the continuous manufacturing of chemical tablet owing to simplified process and low energy consumption.However,due to its complex composition,poor fluidity,poor compressibility,and strong hygroscopicity,the direct compression of traditional Chinese medicine(TCM)powder faces significant challenges,which seriously restrict the industrialization of this technology and continuous manufacturing mode in the field of TCM.This study focused on the applicability of DC of TCM powder.Furthermore,the latest research progresses in improving the tableting performance through specific strategies such as single excipient modification,functional excipient co-processing development,and particle design(such as the construction of porous particles and composite particles)were systematically reviewed.Additionally,this study discussed the key technologies and compatibility requirements of its integration with the continuous manufacturing process,aiming to provide a practical theoretical basis and technical ideas for promoting the development and application of efficient and stable continuous DC technology of TCM tablet.关键词
中药粉末/直接压片/辅料/粒子设计/连续制造Key words
traditional Chinese medicine powder/direct compression/excipients/particle design/continuous manufacturing引用本文复制引用
敖歌,王甜甜,吴彪,柳绪龙,张文锍,张国松,苏瑾..中药粉末直接压片技术的前沿拓展:辅料改性及粒子设计与连续制造的整合[J].中国中药杂志,2026,51(8):2173-2183,11.基金项目
江西中医药大学创新药物研究与开发创新团队项目(CXTD22001) （CXTD22001）
江西中医药大学重点学科建设经费项目(2023jzzdxk018) （2023jzzdxk018）
