转化医学杂志2026，Vol.15Issue(4)：572-577,6.DOI:10.3639/j.issn.2095-3097.2026.04.006
MMP-9/TIMP-1比值与首发急性心肌梗死患者早期恶性室性心律失常的关系
The Relationship Between the MMP-9/TIMP-1 Ratio and Early Malignant Ventricular Arrhythmias in Patients with First-onset Acute Myocardial Infarction
摘要
Abstract
Objective To explore the predictive value of the matrix metalloproteinase-9(MMP-9)/tissue inhibitor of metalloproteinase-1(TIMP-1)ratio for early(≤48 h)malignant ventricular arrhythmia(MVA)in patients with first-onset acute myocardial infarction(AMI).Methods A total of 304 patients with first-onset AMI admitted to the First People's Hospital of Kunshan Affiliated to Gusu College of Nanjing Medical University from May 2024 to April 2025 were selected.According to the occurrence of MVA within 48 hours after AMI symptom onset,patients were divided into the MVA group(69 cases)and the non-MVA group(235 cases).Serum MMP-9,TIMP-1 levels,the MMP-9/TIMP-1 ratio within 24 h after percutaneous coronary intervention,and clinical data were compared between the two groups.The predictive value of the MMP-9/TIMP-1 ratio for early MVA in patients with first-onset AMI was analyzed using receiver operating characteristic(ROC)curve analysis.Multivariate Logistic stepwise regression was used to analyze the influencing factors for early MVA in patients with first-onset AMI.Results Serum MMP-9,TIMP-1 levels,and the MMP-9/TIMP-1 ratio were higher in the MVA group than in the non-MVA group(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of the MMP-9/TIMP-1 ratio for predicting early MVA in patients with first-onset AMI was 0.912(95%CI:0.862-0.957),which was significantly higher than that of serum MMP-9 alone(AUC=0.758,95%CI:0.708-0.815)and TIMP-1 alone(AUC=0.871,95%CI:0.821-0.916)(Z=12.912 and 10.629,both P<0.001).The proportion of Killip class Ⅲ-Ⅳ,white blood cell count,neutrophil count,creatine kinase-MB(CK-MB),and troponin I levels were higher in the MVA group than in the non-MVA group,while serum potassium level and left ventricular ejection fraction(LVEF)were lower(P<0.05).Multivariate logistic stepwise regression analysis showed that Killip class Ⅲ-Ⅳ(OR=2.392),elevated CK-MB(OR=2.050),elevated troponin I(OR=2.522),decreased LVEF(OR=2.000),and an increased MMP-9/TIMP-1 ratio(OR=2.962)were independent risk factors for early MVA in patients with first-onset AMI.Conclusion The MMP-9/TIMP-1 ratio has certain predictive value for early MVA in patients with first-onset AMI,and an increased MMP-9/TIMP-1 ratio is one of the independent risk factors for early MVA in these patients.关键词
心肌梗死/恶性室性心律失常/基质金属蛋白酶9/金属蛋白酶组织抑制剂1Key words
myocardial infarction/malignant ventricular arrhythmia/matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1引用本文复制引用
曾繁龙,周家晖,陈言,高田云,吴霏儿,张梦瑶,刘杰,于宗良..MMP-9/TIMP-1比值与首发急性心肌梗死患者早期恶性室性心律失常的关系[J].转化医学杂志,2026,15(4):572-577,6.基金项目
国家自然科学基金青年科学基金项目(81700737) （81700737）
苏州市科技计划项目(SKY2023028) （SKY2023028）
