神经药理学报2026，Vol.16Issue(1)：12-18,7.DOI:10.3969/j.issn.2095-1396.2026.01.002
Box-Behnken响应面法结合三变量单因素筛选泽泻配方颗粒提取工艺研究
Optimization of the Extraction Process for Alisma Formula Granules Using the Box-Behnken Response Surface Method Integrated with Three-Variable Single-Factor Screening
摘要
Abstract
Objective:To screen the optimal water extraction process for Alisma orientale formula granules.Methods:A three-variable single-factor method was adopted,with extraction time,water addition volume,and extraction frequency as horizontal factors,and acetyl alisma C content and alisma extract rate as evaluation indicators.The Box-Behnken response surface method was used to screen the water extraction process of Alisma formula granules,and the best water extraction process method was selected.Results:The water extraction process of the optimized Alisma orientale formula granules is to add 10 times the amount of water,boil for 1.5 hours,and extract three times.Conclusion:The preferred extraction process is stable and feasible,providing a basis for the large-scale industrial production of Alisma orientale formula granules.关键词
泽泻/配方颗粒/Box-Behnken响应面法/23-乙酰泽泻醇CKey words
alisma orientale/formula granules/Box-Behnken response surface method/23-acetylalismatol C分类
医药卫生引用本文复制引用
李凤丽,孔德伟,张博庸,柴士伟..Box-Behnken响应面法结合三变量单因素筛选泽泻配方颗粒提取工艺研究[J].神经药理学报,2026,16(1):12-18,7.基金项目
河北省中医药管理局科研计划项目(No.T2026088) （No.T2026088）
