神经药理学报2026，Vol.16Issue(1)：23-27,5.DOI:10.3969/j.issn.2095-1396.2026.01.004
和肽素联合TIMI评分对急性ST段抬高型心肌梗死合并心力衰竭患者预后的评估价值
The Evaluation Value of Peptide Combined with TIMI Score for the Prognosis of Patients with Acute ST-Segment Elevation Myocardial Infarction Complicated with Heart Failure
王子帅 1东野鸿方 1刘加齐 1李方江2
作者信息
- 1. 河北北方学院 研究生学院,张家口,075000,中国
- 2. 河北北方学院附属第一医院心血管内科,张家口,075000,中国
- 折叠
摘要
Abstract
Objective:To investigate the prognostic value of serum copeptin level combined with thrombolysis in myocardial infarction(TIMI)score in patients with acute ST-segment elevation myocardial infarction(STEMI)complicated with heart failure(HF).Methods:A total of 107 patients with HF after acute myocardial infarction were selected for TIMI score.According to the score results,they were divided into low-risk group(0～3 points)with 31 cases,medium-risk group(4～6 points)with 42 cases,and high-risk group(7～14 points)with 34 cases.According to the level of copeptin,they were divided into low copeptin group(60 cases)and high copeptin group(47 cases).The serum copeptin levels and TIMI scores of patients with low,medium and high-risk groups of TIMI and patients with low and high copeptin groups with recurrence/no MACE within 180 days after discharge were compared.Results:The levels of serum copeptin in the low,medium and high-risk groups were(17.59±3.06),(22.76±5.01)and(43.04±11.55)pmol·L-1,respectively.The level of copeptin increased with the increase of TIMI score,and the difference was statistically significant(P<0.05).After 180 days of follow-up,there were 29 cases of major adverse cardiac events(MACE)and 78 cases without MACE.The serum copeptin level in patients with recurrent MACE was significantly higher than that in patients without MACE[(40.70±12.22)vs(20.13±4.92)pmol·L-1,P<0.05].The TIMI score of patients with recurrent MACE was significantly higher than that of patients without MACE[(8±4)vs(5±3),P<0.05].During the 180-day clinical follow-up,the cumulative incidence of cardiac death in the high copeptin group was higher than that in the low copeptin group(P<0.05).Conclusion:Serum copeptin combined with TIMI score has positive clinical reference value for prognosis evaluation of STEMI patients with HF.关键词
和肽素/心肌梗死溶栓治疗危险评分/ST段抬高型心肌梗死/心力衰竭/生物标志物Key words
copeptin/TIMI risk score for myocardial infarction thrombolytic therapy/STEMI/heart failure/biomarker分类
医药卫生引用本文复制引用
王子帅,东野鸿方,刘加齐,李方江..和肽素联合TIMI评分对急性ST段抬高型心肌梗死合并心力衰竭患者预后的评估价值[J].神经药理学报,2026,16(1):23-27,5.
