神经药理学报2026，Vol.16Issue(1)：51-57,7.DOI:10.3969/j.issn.2095-1396.2026.01.007
骨陷窝-小管网络重塑与骨质疏松—从组织液流动到骨力学生物学的微解剖进展
Osteocyte Lacunar-Canalicular Network Remodeling and Osteoporosis—Microanatomical Advances from Interstitial Fluid Flow to Bone Mechanobiology
摘要
Abstract
Osteoporosis features reduced bone mass and damaged microarchitecture,yet some individuals sustain fragility fractures despite normal bone mineral density(BMD),showing that BMD alone cannot capture fracture resistance.Bone strength is governed by bone quality,integrating mass,microarchitecture,matrix material properties,and osteocyte activity.The osteocyte lacunar-canalicular network(LCN)is the central microanatomical pathway for mechanotransduction and metabolic exchange:it converts mechanical loading into interstitial fluid-flow-mediated cues and propagates signals that tune bone formation and resorption.Studies indicate that aging and disease can reduce LCN connectivity and disturb its geometry,leading to inefficient transport and blunted cellular responses;consequently,microdamage repair and mechanical adaptation decline even when bone mass appears preserved.This review summarizes LCN-centered,multi-physics mechanisms underlying osteoporosis heterogeneity and highlights opportunities for improved risk stratification and targeted interventions.关键词
骨质疏松症/骨细胞/骨陷窝-小管网络(LCN)/力学生物转导Key words
osteoporosis/osteocyte/lacunar-canalicular network/mechanotransduction分类
医药卫生引用本文复制引用
杨天乐..骨陷窝-小管网络重塑与骨质疏松—从组织液流动到骨力学生物学的微解剖进展[J].神经药理学报,2026,16(1):51-57,7.基金项目
肇庆医学高等专科学校 2024 年校级课程建设示范项目(No.2024-ks5) （No.2024-ks5）
