摘要
Abstract
In recent years,with the increasing clinical use and intensity of carbapenem antibiotics,the resistance rate of Acinetobacter baumannii to carbapenem antimicrobial agents has shown a gradual upward trend.Carbapenem-resistant Acinetobacter baumannii is now widely distributed globally,with detection rates continuously rising,making it one of the major global public health issues.The resistance mechanisms of carbapenem-resistant Acinetobacter baumannii are complex,involving the production of carbapenemases,overexpression of efflux pumps,deletion or altered expression of outer membrane proteins,biofilm formation,and changes in drug binding sites.For infections caused by multidrug-resistant Acinetobacter baumannii,the number of clinically available antimicrobial agents is diminishing,making infection control challenging and resulting in high patient mortality rates.Therefore,clinicians should actively prevent multidrug-resistant Acinetobacter baumannii,optimize antimicrobial use and infection control,and actively seek new drugs and treatment strategies to address carbapenem-resistant Acinetobacter baumannii.This review summarizes the current status of infections caused by carbapenem-resistant Acinetobacter baumannii and its resistance mechanisms,providing scientific basis for future antibiotic research,clinical guidance,and prevention strategies.关键词
鲍曼不动杆菌/碳青霉烯类耐药/感染现状/耐药机制Key words
acinetobacter baumannii/carbapenem resistance/infection status/resistance mechanisms分类
医药卫生
