肿瘤防治研究2026，Vol.53Issue(4)：267-273,7.DOI:10.3971/j.issn.1000-8578.2026.25.0696
代谢综合征与乳腺癌:一项双向两样本孟德尔随机化研究的因果推断
Causal Inference on Association Between Metabolic Syndrome and Breast Cancer:A Bidirectional Two-Sample Mendelian Randomization Study
摘要
Abstract
Objective To investigate the causal relationship between metabolic syndrome and breast cancer by using a bidirectional two-sample Mendelian randomization(MR)approach.Methods Genome-wide association study(GWAS)summary statistics for metabolic syndrome and breast cancer were acquired from the Integrative Epidemiology Unit GWAS database and the GWAS Catalog,with populations encompassing the United States and East Asia.A bidirectional causal design was employed:a forward analysis with metabolic syndrome as the exposure and breast cancer as the outcome,followed by a reverse analysis wherein their roles were interchanged.The inverse-variance weighting(IVW)method was primarily used for effect estimation,supplemented by MR-Egger regression,the weighted median method,the simple mode method,and the weighted mode method.Instrument variable strength was screened using the F-statistic(F>10).Robustness of the results was assessed through heterogeneity tests,horizontal pleiotropy tests,forest plots,and leave-one-out sensitivity analyses.Results The IVW analysis indicated no significant causal relati-onship between metabolic syndrome and breast cancer(OR=1.00,95%CI:0.97-1.03),P>0.05).Sensitivity analyses yielded consistent results,suggesting the good robustness of the study findings.Conclusion This study found no evidence to support a causal relationship,either positive or negative,between metabolic syndrome and breast cancer.关键词
代谢综合征/乳腺癌/双向两样本孟德尔随机化Key words
Metabolic syndrome/Breast cancer/Bidirectional two-sample Mendelian randomization分类
医药卫生引用本文复制引用
杜疑,薛梦瑶,陈慧颖,孙颖,罗天裕,孙海东..代谢综合征与乳腺癌:一项双向两样本孟德尔随机化研究的因果推断[J].肿瘤防治研究,2026,53(4):267-273,7.基金项目
Shenzhen Science and Technology Program(No.JCYJ20240813160621028) （No.JCYJ20240813160621028）
Futian Healthcare Research Project(No.FTWS075) （No.FTWS075）
Foundation of Key Clinical Specialty Construction Project in Futian District,Shenzhen City 深圳市自然科学基金面上项目(JCYJ202408-13160621028) （JCYJ202408-13160621028）
深圳市福田区卫生健康系统科研项目(FTWS075) （FTWS075）
深圳市福田区临床重点专科建设经费资助 （）
