肿瘤防治研究2026，Vol.53Issue(4)：274-280,7.DOI:10.3971/j.issn.1000-8578.2026.25.0751
云南省4892例结直肠癌患者生存的影响因素分析
Factors Affecting Survival of 4892 Patients with Colorectal Cancer in Yunnan Province
摘要
Abstract
Objective To analyze survival outcomes and influencing factors among patients with colorectal cancer in Yunnan Province.Methods Clinical data were retrospectively collected from 4 892 patients with colorectal cancer.Survival data were obtained through follow-up.Overall survival(OS)was calculated by using the Kaplan-Meier method.Univariate analysis was performed by applying the log-rank test.Meanwhile,multivariate analysis employed the Cox proportional hazards regression model.Results The 1-,3-,5-,and 10-year OS rates for the entire cohort were 91.90%,74.40%,64.40%,and 28.70%,respectively.Univariate analysis revealed that age,ethnicity,region,differentiation grade,TNM stage,clinical stage,metastatic status,histological type,and treatment modality(chemotherapy,radiotherapy,and surgery)were associated with patient prognosis(all P<0.05).Multivariate analysis identified age(HR=1.250),region(HR=1.262),differentiation grade(HR=0.761),clinical stage(HR=3.128),and treatment modality(chemotherapy,HR=0.644;radiotherapy,HR=1.605;surgery,HR=0.384)as independent factors affecting survival prognosis in patients with colorectal cancer(all P<0.001).Conclusion Age,region,clinical stage,and treatment moda-lity are independent factors influencing survival among patients with colorectal cancer in Yunnan Province.In clinical practice,these factors should be integrated to develop individualized prevention and treatment strategies,thereby improving patient outcomes.关键词
结直肠癌/生存分析/预后因素/回顾性研究Key words
Colorectal cancer/Survival analysis/Prognostic factors/Retrospe-ctive study分类
医药卫生引用本文复制引用
蔡瑞琪,杨志坚,杨颜颜,马国玉,庞钰莹,张梦娇,罗镭,李四乐,赵敏..云南省4892例结直肠癌患者生存的影响因素分析[J].肿瘤防治研究,2026,53(4):274-280,7.基金项目
2024年云南省高层次卫生健康人才—医学学科带头人(流行病学)培养项目(D-2024014) （流行病学）
昆明医科大学2024年度校级专业学位研究生教学案例库建设项目(2024-4) （2024-4）
昆明医科大学2025年研究生教育管理创新基金项目(2025GL005) （2025GL005）
云南省肿瘤医院2025年教学联盟本科教育项目(JXCG202501) 2024 Yunnan Province High-Level Health Talent Cultivation Prog-ram—Medical Discipline Leaders(Epid-emiology)(No.D-2024014) （JXCG202501）
Kunming Medical University 2024 University-Le-vel Professional Degree Graduate Tea-ching Case Library Construction Project(No.2024-4) （No.2024-4）
Kunming Medical Uni-versity 2025 Graduate Education Mana-gement Innovation Fund Project(No.2025GL005) （No.2025GL005）
Yunnan Provincial Can-cer Hospital 2025 Teaching Alliance Undergraduate Education Achievement Cultivation Project(No.JXCG202501) （No.JXCG202501）
