肿瘤防治研究2026，Vol.53Issue(4)：289-300,12.DOI:10.3971/j.issn.1000-8578.2026.25.0759
VEGF抑制剂的抗肿瘤相关常见不良反应及其干预策略
VEGF Inhibitor-Associated Side Effects in Antitumor Therapy and Intervention Strategies
摘要
Abstract
Vascular endothelial growth factor(VEGF)inhibitors are drugs that target and inhibit tumor angiogenesis.By blocking the signaling pathway of VEGF and its receptor,they suppress tumor proliferation and play a crucial role in tumor treatment.However,their side effects,such as hypertension,proteinuria,hand-foot skin reactions,and myelosuppression,during treatment seriously affect patients'treatment compliance and quality of life.The development of intervention strategies for the side effects of VEGF inhibitors is of great importance for tumor treatment.This article reviews the clinical characteristics and toxic mechanisms of common side effects caused by VEGF inhibitors during tumor treatment and summarizes intervention strategies that combine traditional Chinese and Western medicines.Drug dosages were precisely monitored and adjusted to achieve antitumor treatment.Patients'discomfort symptoms are improved through prescriptions that act by tonifying qi and promoting blood circulation,strengthening the spleen,and tonifying the kidney.The combination of traditional Chinese and Western medicines is used to treat patients,thus providing a safe and effective treatment plan for patients with cancer.关键词
VEGF抑制剂/抗肿瘤/高血压/蛋白尿/手足皮肤反应/骨髓抑制/干预策略Key words
VEGF inhibitor/Antitumor/Hypertension/Proteinuria/Hand-foot skin reaction/Myelosupp-ression/Intervention strategy分类
医药卫生引用本文复制引用
刘璐,孙婉婷,姚舒宁,陈珍雨,王跃飞,杨静..VEGF抑制剂的抗肿瘤相关常见不良反应及其干预策略[J].肿瘤防治研究,2026,53(4):289-300,12.基金项目
Special Project for Technological Innovation in New Productive Forces of Modern Chinese Medicines(No.24ZXZKSY00010) 现代中药新质生产力科技创新工程专项(24ZXZKSY00010) （No.24ZXZKSY00010）
