肿瘤防治研究2026，Vol.53Issue(4)：301-315,15.DOI:10.3971/j.issn.1000-8578.2026.26.0023
三氧化二砷在实体瘤中的作用机制与递送技术研究进展
Research Advances in Mechanisms of Action and Delivery Technologies of Arsenic Trioxide Against Solid Tumors
摘要
Abstract
Arsenic trioxide(ATO)serves as a component of traditional Chinese medicine and a modern anticancer agent,demonstrating remarkable efficacy in the long-term treatment of acute promyelocytic leukemia.With increasing research into its application in solid tumors,ATO's diverse mechanisms of action and potential clinical value have attracted widespread attention.ATO can inhibit tumor cell proliferation by inducing various forms of cell death,such as apoptosis,autophagy,pyroptosis,necroptosis,and ferroptosis,as well as by regulating cell differentiation.Moreover,its modulatory effects on the tumor immune microenvironment provide a new aspectto its antitumor activity.Nevertheless,the clinical application of ATO in solid tumors faces challenges such as low bioavailability,inadequate targeting,and adverse effects.The development of nanocarriers and targeted delivery systems has emerged asa key strategy for enhancing the therapeutic efficacy of ATO.This review systematically summarizes the multiple mechanisms of action of ATO in solid tumors and recent advances in nanodelivery technologies,explores the potential of ATO-based combination therapies,and discusses future directions,aiming to provide a theoretical foundation and practical guidance for the clinical application of ATO in solid tumors.关键词
三氧化二砷/实体瘤/纳米递送/肿瘤免疫/联合治疗Key words
Arsenic trioxide/Solid neoplasm/Nanoparticle/Immunotherapy/Combination therapy分类
医药卫生引用本文复制引用
刘磊,查育锋,魏志力..三氧化二砷在实体瘤中的作用机制与递送技术研究进展[J].肿瘤防治研究,2026,53(4):301-315,15.基金项目
Qinchuangyuan Traditional Chinese Medicine Industry Innovation Cluster Project(Participating Ins-titutions:University of Traditional Chinese Medicine,Medical Institutions)(No.L2024-QCY-ZYYJJQ-272) 秦创原中医药产业创新聚集区项目(中医药大学、医疗机构)(L2024-QCY-ZYYJJQ-272) （Participating Ins-titutions:University of Traditional Chinese Medicine,Medical Institutions）
