肿瘤相关巨噬细胞铁死亡在肝细胞癌免疫逃逸中的作用及中医药调控研究进展
Role of Macrophage Ferroptosis in Immune Evasion of Hepatocellular Carcinoma and Research Progress on Traditional Chinese Medicine Intervention
摘要
Abstract
Hepatocellular carcinoma(HCC)develops within a profoundly immunosuppressive tumor immune microenvironment(TIME),which limits the efficacy of immunotherapy.Polarization of tumor-associated macrophages(TAMs)toward a pro-tumorigenic M2 phenotype is a major driver of immune escape.Ferroptosis,an iron-dependent regulated cell death program,intersects with hepatic iron metabolism and immune regulation and thus offers promising points of therapeutic intervention.This review systematically elucidates the mechanistic role of TAM ferroptosis in HCC immune evasion and highlights a"bidirectional regulation"intervention strategy grounded in the Traditional Chinese medicine(TCM)principle of"fortifying healthy qi and eliminating pathogens"(Fuzheng Quxie).This strategy employs"eliminating pathogens"(Quxie)approaches to exploit the metabolic vulnerability of M2-like TAMs and precisely induce their ferroptosis.Moreover,it utilizes"fortifying healthy qi"(Fuzheng)approaches to protect M1-like TAMs and CD8+T cells from oxidative damage.This parallel"induction-protection"paradigm demonstrates the unique advantages of TCM in systemically remodeling TIME through multitarget synergistic actions.Accordingly,precision regulation of TAM ferroptosis based on the Fuzheng Quxie theory represents a promising integrative Chinese-Western medicine strategy for overcoming current bottlenecks in HCC immunotherapy,although its clinical translational potential warrants further validation.关键词
肝细胞癌/肿瘤相关巨噬细胞/铁死亡/免疫逃逸/中医药Key words
Hepatocellular carcinoma/Tumor-associated macrophages/Ferroptosis/Immune escape/Traditional Chinese medicine分类
医药卫生引用本文复制引用
彭金香,李晓娟,卢曼,徐新华,舒孟仙,吴沣..肿瘤相关巨噬细胞铁死亡在肝细胞癌免疫逃逸中的作用及中医药调控研究进展[J].肿瘤防治研究,2026,53(4):316-324,9.基金项目
2024 Enshi Prefecture"Qihang"Special Science and Technology Program （）
Hubei Administration of Traditional Chinese Medicine Research Program(No.ZY2023Q028) （No.ZY2023Q028）
National Natural Science Foundation of China,General Program(No.81979728) （No.81979728）
2022 Ministry of Education Industry-University Collaborative Education Program(No.220505181164558) （No.220505181164558）
2023 Key Special Program for Traditional Chinese Medicine of Hubei University of Chinese Medicine （）
Enshi Tujia and Miao Autonomous Prefecture Central Hospital Research Program(No.2023ZDSYS11) 2024年恩施州"启航专项"科技计划项目 （No.2023ZDSYS11）
湖北省中医药管理局科研项目(ZY2023Q028) （ZY2023Q028）
国家自然科学基金面上项目(81979728) （81979728）
2022年度教育部产学合作协同育人项目(220505181164558) （220505181164558）
2023年度湖北中医药大学中医药重点专项 （）
恩施土家族苗族自治州中心医院科研项目(2023ZDSYS11) （2023ZDSYS11）
