摘要
Abstract
Objective:To analyze the diagnostic value of microalbuminuria(mAlB),β2-microglobulin(β2-MG),transferrin(TRF),and albumin-to-creatinine ratio(ACR)in early-stage diabetic nephropathy(DN).Method:A total of 100 patients with type 2 diabetes mellitus(T2DM)and 100 patients with DN were respectively enrolled as the observation group and control group.Morning urine samples were collected for detection of mAlB,β2-MG,TRF and ACR levels.Multivariate logistic regression analysis was performed to identify risk factors for DN development.The diagnostic values of individual and combined biomarkers were evaluated using receiver operating characteristic(ROC)curve and nomogram modeling.Result:Levels of mAlB,β2-MG,TRF and ACR were significantly elevated in the urine of patients with DN,with mAlB,TRF and ACR showing significant associations with DN development in patients with T2DM.ROC curve demonstrated that the combined detection of mAlB,TRF and ACR exhibited superior diagnostic value compared to individual markers,while the nomogram model confirmed the reliability of their predictive performance.Conclusion:The elevation of urinary mAlB,TRF and ACR are associated with the development of DN,and their combined detection demonstrates superior diagnostic value compared to individual measurements.关键词
糖尿病肾病/尿微量白蛋白/β2-微球蛋白/转铁蛋白/尿白蛋白/肌酐比值Key words
Diabetic nephropathy/Urinary microalbumin/β2-microglobulin/Transferrin/Urinary albumin-to-creatinine ratio
