中国中西医结合杂志2026，Vol.46Issue(4)：424-430,7.DOI:10.7661/j.cjim.20260225.005
温阳中药治疗糖尿病肾病网状Meta分析
Network Meta-analysis of Warm-Yang Chinese Herbal Medicine in the Treatment of Diabetic Kidney Disease
摘要
Abstract
Objective To systematically evaluate the clinical efficacy and safety of warm-yang Chinese herbal medicine in treating diabetic kidney disease(DKD)with yang deficiency syndrome.Methods Randomized controlled trials(RCTs)on warm-yang Chinese herb medicine for DKD were retrieved from eight databases.Meta-analysis and network meta-analysis were conducted using RevMan 5.3 and Stata 16.Results Thirty-three studies involving 2 725 DKD patients and nine warm-yang herbal medicines combined with routine treatment(RT)were included.Meta-analysis showed that compared with RT alone,the efficacy of combined warm-yang Chinese herbal medicine was better than that of RT in terms of clinical efficacy rate,Chinese medicine(CM)syndrome score,renal function,blood glucose level.Network Meta-analysis revealed:Shipisan ranked highest for improving overall clinical efficacy rate;Gualou Qumai Tang was optimal for alleviating CM symptoms and reducing fasting and postprandial blood glucose;Shenqiwan was best for reducing serum creatinine,24-hour urinary protein,and glycated hemoglobin;Zhenwu Tang+Lizhong Wan was superior in lowering blood urea nitrogen.Adverse reactions primarily involved gastrointestinal and nervous systems.Conclusions The combination of warm-yang Chinese herbal medicine with RT can improve clinical efficacy rate,alleviate symptoms,and benefit renal function and glycemic control in DKD patients with yang deficiency.This integrated approach provides a reference for clinical practice,further validation through more high-quality studies is warranted.关键词
中医药/糖尿病肾病/疗效/安全性/温阳/网状Meta分析Key words
Chinese medicine/diabetic kidney disease/efficacy/safety/warm-yang/network Meta-analysis引用本文复制引用
林铭钐,冯文娟,王志晨,邱馨锐,杨朝阳,李灿东..温阳中药治疗糖尿病肾病网状Meta分析[J].中国中西医结合杂志,2026,46(4):424-430,7.基金项目
国家重点研发计划(No.2023YFC3503000) （No.2023YFC3503000）
