中国中西医结合杂志2026，Vol.46Issue(4)：496-500,5.DOI:10.7661/j.cjim.20251129.154
肾性贫血病理生理机制阐释"肾精-髓-血"理论
Pathophysiology of Chronic Kidney Disease-Related Anemia:Elucidation of"Shen Essence-Marrow-Blood"
摘要
Abstract
Anemia is a common complication of chronic kidney disease(CKD),primarily caused by impaired kidney function leading to insufficient erythropoietin(EPO)production and subsequent bone marrow erythropoietic dysfunction.This pathogenesis is highly consistent with the theory of"Shen essence-marrow-blood"in Chinese medicine(CM),which posits that deficiency of Shen essence impairs marrow generation and thereby disrupts blood production.In CM framework,the Shen is regarded as the root of yin and yang for all five zang organs.Consequently,Shen deficiency can lead to multi-organ dysfunction,which further compromises hematopoiesis.Conversely,inadequate blood supply fails to nourish the organs,creating a vicious cycle.Grounded in the context of CKD-related anemia,this paper explores the intersection of classical CM theory and modern medical evidence.It aims to explore the scientific connotation of the"Shen essence-marrow-blood"theory,thereby providing a theoretical foundation for developing integrative strategies to improve the management of CKD-related anemia.关键词
肾性贫血/肾精-髓-血/慢性肾脏病/病理生理/中西医结合Key words
anemia/Shen essence-marrow-blood/chronic kidney disease/pathophysiology/integrative medicine引用本文复制引用
朱希焕,王怀玉,宗玉涵,周梦茹,金璐瑶,王济,李平..肾性贫血病理生理机制阐释"肾精-髓-血"理论[J].中国中西医结合杂志,2026,46(4):496-500,5.基金项目
北京市自然科学基金海淀原始创新联合基金项目(No.L232118) （No.L232118）
国家中医药管理局高水平中医药重点学科建设项目(No.zyyzdxk-2023251) （No.zyyzdxk-2023251）
