中医临床研究2026，Vol.18Issue(2)：21-27,7.DOI:10.3969/j.issn.1674-7860.2026.02.003
基于古籍文献挖掘甲状腺相关眼病用药规律研究
Study on medication patterns for thyroid-associated ophthalmopathy based on data mining of ancient Chinese medical literature
摘要
Abstract
Objective:To explore the medication patterns for treating thyroid-associated ophthalmopathy(TAO)based on ancient Chinese medical literature.Methods:Data was retrieved from all the entries mentioning TAO in the Zhong Hua Yi Dian(《中华医典》).After applying inclusion and exclusion criteria and screening the entries,a database was constructed using Microsoft Office Excel 2016.The raw data were subsequently subjected to statistical analysis using SPSS Statistics 23.0 and SPSS Modeler 18.0 software to uncover the medication patterns for TAO.Results:A total of 42 relevant documents were included.Among them,the high-frequency prescriptions were Mofeng Gao(摩风膏),Fenzhu San(分珠散),Xiefei Tang(泻肺汤),and Xuanming Wan(宣明丸).The top 25 high-frequency traditional Chinese medicines(TCMs)used,in descending order of frequency,were Danggui(Radix Angelicae Sinensis),Huangqin(Radix Scutellariae),Fangfeng(Radix Saposhnikoviae),Gancao(Radix Glycyrrhizae),Chishao(Radix Paeoniae Rubra),Zhizi(Fructus Gardeniae),and so forth.The major effects of these high-frequency TCM were heat-clearing and exterior-releasing,with cold and warm natures being the most prevalent,among which bitter,sweet,and pungent flavors were the most dominant.They mainly entered the liver,lung,and heart meridians.Association rule analysis showed that the major high-frequency couplet medicinals were Danggui-Chishao,Dahuang(Radix et Rhizoma Rhei)-Zhizi,Huangqin-Mangxiao(Natrii Sulfas),Dahuang-Mangxiao,and Danggui-Fangfeng.Cluster analysis divided the high-frequency TCM into four categories:Category I mainly focused on draining liver heat,Category II comprised mainly blood-regulating and exterior-releasing herbs,Category III contained Longdan(Radix et Rhizoma Gentianae)and Zhizi,both of which had heat-clearing effects,and Category IV comprised herbs with diuretic and dampness-eliminating functions.Conclusion:The medication patterns for treating TAO in ancient texts can provide theoretical support and a practical foundation for modern physicians in diagnosis,treatment,and clinical medication.关键词
甲状腺相关眼病/《中华医典》/用药规律/数据挖掘Key words
Thyroid-associated ophthalmopathy/Zhong Hua Yi Dian/Medication rule/Data mining分类
医药卫生引用本文复制引用
王菲,屈之榆,王萍,徐梦娇,李闪闪,郭盼盼,余丹丹,燕树勋..基于古籍文献挖掘甲状腺相关眼病用药规律研究[J].中医临床研究,2026,18(2):21-27,7.基金项目
河南省中医药传承与创新人才工程(仲景工程)中医药拔尖人才(CZ0237-02) （仲景工程）
郑州市科技惠民计划(2021KJHM0017). （2021KJHM0017）
