中医临床研究2026，Vol.18Issue(2)：81-87,7.DOI:10.3969/j.issn.1674-7860.2026.02.012
灵宝护心丹联合针灸治疗老年冠心病慢性心力衰竭的临床效应
Clinical efficacy of Lingbao Huxin Dan combined with acupuncture in treating patients with chronic heart failure due to coronary heart disease of Qi deficiency-blood stasis syndrome
摘要
Abstract
Objective:To evaluate the clinical efficacy of Lingbao Huxin Dan(灵宝护心丹)combined with acupuncture at Neiguan acupoit(PC6)in treating patients with chronic heart failure(CHF)due to coronary heart disease(CHD)of Qi deficiency-blood stasis syndrome(气虚血瘀证).Methods:Two hundred patients were randomized into control and experimental groups(100 cases in each).The control group received standard Western therapy,while the experimental group additionally received Lingbao Huxin Dan and bilateral Neiguan acupuncture for 4 weeks.Clinical efficacy and serum levels of Lp-PLA2,sST2,and NT-proBNP were compared.Results:Ninety controls and 95 experimental cases were analyzed.The total effective rate in the experimental group was significantly higher that the control group(χ²=11.623,P=0.009).Post-treatment Lp-PLA2,sST2,and NT-proBNP were decreased in both groups(P<0.05).Generalized estimating equations indicated that reductions in TCM syndrome scores,Lp-PLA2,sST2,and NT-proBNP were time-dependent(P<0.01),while only Lp-PLA2 reduction was group-dependent(P<0.01).Group-time interactions were significant(P<0.01).Conclusion:Lingbao Huxin Dan combined with Neiguan acupuncture can ameliorate symptoms and biomarkers in CHF patients with CHD of Qi deficiency-blood stasis syndrome.关键词
冠状动脉粥样硬化性心脏病/慢性心力衰竭/气虚血瘀证/中成药Key words
Coronary heart disease/Chronic heart failure/Qi deficiency-blood stasis syndrome/Chinese patent medicine分类
医药卫生引用本文复制引用
周炜,徐慧竹,陈啸,曹燕萍,任雨婷,侯小慧,戴佳韵,董玲慧..灵宝护心丹联合针灸治疗老年冠心病慢性心力衰竭的临床效应[J].中医临床研究,2026,18(2):81-87,7.基金项目
无锡市卫生计生委科研项目计划(Q202244). （Q202244）
