中医临床研究2026，Vol.18Issue(5)：124-131,8.DOI:10.3969/j.issn.1674-7860.2026.05.019
温针灸联合来曲唑对肾虚血瘀型排卵障碍性不孕症患者子宫内膜容受性影响的疗效观察
Observation on the effect of warm acupuncture combined with letrozole on endometrial receptivity in patients with kidney deficiency and blood stasis type ovulatory disorder infertility
摘要
Abstract
Objective:To evaluate the clinical efficacy of warm acupuncture combined with letrozole for treating ovulatory disorder infertility(ODI)of kidney deficiency and blood stasis type,and to investigate its effect on endometrial receptivity(ER).Methods:A total of 62 patients diagnosed with ODI of kidney deficiency and blood stasis type treated at Meishan Hospital Affiliated with Chengdu University of Traditional Chinese Medicine(TCM)from January to September 2024 were randomly divided and assigned to either a control group or an observation group,with 31 patients in each.The control group received letrozole treatment,while the observation group received warm acupuncture in addition to letrozole.Both groups received treatment for three consecutive menstrual cycles.Endometrial thickness,uterine artery hemodynamic parameters,endometrial blood perfusion,maximum follicle diameter,TCM syndrome scores,and Salle scores were measured before and after treatment.Pregnancy outcomes were recorded during a 3-month follow-up period.Results:After treatment,endometrial thickness,VI,FI,and VFI in the observation group increased compared with baseline(P<0.05),while uterine artery PI,RI,and S/D decreased(P<0.05);these changes were greater than those observed in the control group(P<0.05).Salle scores in the observation group increased compared with baseline(P<0.05)and were higher than those of the control group(P<0.05).The maximum follicular diameter increased in both groups after treatment(P<0.05),with the observation group showing higher values than the control group(P<0.05).The TCM syndrome scores in the observation group decreased compared with baseline(P<0.05)and was lower than that of the control group(P<0.05).The pregnancy rate in the observation group was 44.8%,significantly higher than 19.4%in the control group(P<0.05).The total clinical effective rate in the observation group was significantly higher than the control group(P<0.05).Conclusion:Warm acupuncture can improve ER,promote follicular development,optimize TCM syndromes,and increase pregnancy rates,and its overall therapeutic effect is better than that of letrozole monotherapy.关键词
温针灸/排卵障碍性不孕症/子宫内膜容受性/肾虚血瘀Key words
Warm acupuncture/Ovulatory disorder infertility/Endometrial receptivity/Kidney deficiency and blood stasis分类
医药卫生引用本文复制引用
何淑敏,易琼,袁逢娟,何星睿,周小丁..温针灸联合来曲唑对肾虚血瘀型排卵障碍性不孕症患者子宫内膜容受性影响的疗效观察[J].中医临床研究,2026,18(5):124-131,8.基金项目
眉山市中医药研究所中医药专项(ZYY202318) （ZYY202318）
眉山市科学技术计划项目(kjzd202293) （kjzd202293）
成都中医药大学"杏林学者"学科人才科研提升计划. （）
