中药新药与临床药理2026，Vol.37Issue(4)：748-754,7.DOI:10.19378/j.issn.1003-9783.2026.04.017
SIRTs在心力衰竭机制中的作用及中医药干预的研究进展
Research Progress on the Role of SIRTs in the Mechanisms of Heart Failure and Interventions by Traditional Chinese Medicine
摘要
Abstract
Heart failure is a clinical syndrome caused by multiple etiologies,severely affecting patients'quality of life and prognosis.Modern research has found that sirtuins(SIRT),represented by SIRT1,SIRT3,SIRT4,and SIRT6,are involved in the occurrence and progression of heart failure through multiple pathways.These include regulating cellular energy metabolism,oxidative stress responses,myocardial tissue fibrosis,myocardial cell mitochondrial energy metabolism,and apoptosis.Extensive studies have shown that traditional Chinese medicine(TCM),including herbal monomers and compound formulas,can improve heart failure by modulating the expression and activity of SIRT.This leads to enhanced myocardial function,reduced oxidative stress,and alleviated cardiac remodeling.This article reviews the role of SIRT in the pathogenesis of heart failure and summarizes research on TCM interventions targeting SIRTs for heart failure,aiming to provide more insights for the prevention and treatment of heart failure with TCM.关键词
沉默信息调节因子 2 相关酶/心力衰竭/中医药/研究进展Key words
SIRT/heart failure/TCM/research progress分类
医药卫生引用本文复制引用
郭俊池,张明妍,赵英强,路美娟..SIRTs在心力衰竭机制中的作用及中医药干预的研究进展[J].中药新药与临床药理,2026,37(4):748-754,7.基金项目
国家自然科学基金面上项目(82374619) （82374619）
天津市卫生健康委员会中医中西医结合科研课题(2023027) （2023027）
天津市教委科研计划重点项目(2021ZD028). （2021ZD028）
