遵义医科大学学报2026，Vol.49Issue(4)：456-462,7.
纤溶酶原激活物抑制剂1的时间动态改变在创伤性凝血功能障碍中的研究进展
Progress and clinical significance of temporal changes in plasminogen activator inhibitor-1 in trauma-induced coagulopathy
摘要
Abstract
Trauma-induced coagulopathy(TIC)is a temporally dependent coagulation imbalance closely asso-ciated with early hemorrhage and late thrombotic complications following trauma.Plasminogen activator inhibitor-1(PAI-1)plays a crucial regulatory role in the progression of TIC.Clinical sequential monitoring and experi-mental studies indicate that the early phase of trauma is characterized by fibrinolytic activation dominated by en-dothelial release of tissue-type plasminogen activator(tPA).Subsequently,under the influence of sustained hy-poperfusion and inflammatory responses,PAI-1 expression gradually increases,typically peaking 6 to 24 hours post-injury,shifting the fibrinolytic state from activation to inhibition or even shutdown.The temporal rise in PAI-1 not only contributes to maintaining hemostatic stability but may also associated with microvascular thrombo-sis and organ dysfunction.Therefore,a clinical TIC staging assessment based on the temporal dynamics of PAI-1 facilitates the identification of distinct fibrinolytic phenotypes and their respective risk windows,providing a theoretical basis for anti-fibrinolytic treatment decisions and thrombotic risk stratification.This review focuses on the temporal evolution of PAI-1 in TIC and its clinical implications.关键词
创伤性凝血病/纤溶酶原激活物抑制剂-1/纤溶表型/时间动力学/风险分层Key words
trauma-induced coagulopathy/plasminogen activator inhibitor-1/fibrinolytic phenotype/temporal dynamics/risk stratification分类
医药卫生引用本文复制引用
吴瑾,段海真..纤溶酶原激活物抑制剂1的时间动态改变在创伤性凝血功能障碍中的研究进展[J].遵义医科大学学报,2026,49(4):456-462,7.基金项目
国家自然科学基金资助项目(NO:82260385) （NO:82260385）
贵州省急诊医学临床医学研究中心[NO:黔科合平台LCZX(2025)004] （2025）
贵州省科技计划项目[NO:黔科合基础-MS(2025)388]. （2025）
