中医药学报2026，Vol.54Issue(5)：40-44,5.DOI:10.19664/j.cnki.1002-2392.260094
基于玄府气液学说探讨银屑病、湿疹生物制剂治疗后的表型转换现象
Exploration on the Phenomenon of Phenotypic Transition Following Biological Agent Treatment in Psoriasis,Eczema Based on the Theory of Xuanfu Qi Fluids
摘要
Abstract
Treatment with biological agents may lead to eczema-like changes in patients with psoriasis and psoriasis-like changes in patients with eczema,and this phenotypic switching phenomenon is attracting more and more attention,whose molecular biological mechanism may be related to the dysregulation of the Th1/Th2 balance,and for which there is no clear therapeutic solution.Based on the Xuanfu qi fluids theory,this paper describes the evolution of the pathogenesis of psoriasis and eczema.In the course of treatment,the biological agents may improperly regulate qi and fluids transport,which ultimately leads to dampness on the outside and qi and blood dryness on the inside;dryness is present on the surface,while dampness is stagnant on the inside,which is manifested as the phenomenon of phenotypic transformation on the skin.For this complex dry-damp presentation,therapy must combine pungent-moistening agents to unblock the orifices with bland herbs to promote diuresis,thereby normalizing qi fluids dynamics without fostering pathogens or injuring upright qi.An illustrative case is presented to showcase this approach to managing pattern transition.关键词
银屑病/湿疹/生物制剂/玄府气液学说Key words
Psoriasis/Eczema/Biological agents/Theory of Xuanfu qi fluids分类
医药卫生引用本文复制引用
刁若涵,段行武,曲天歌,田野,黄敏,高玥璇,邓欢欢,李小婷..基于玄府气液学说探讨银屑病、湿疹生物制剂治疗后的表型转换现象[J].中医药学报,2026,54(5):40-44,5.基金项目
国家自然科学基金项目(82074436) （82074436）
