中华中医药学刊2026，Vol.44Issue(4)：81-85,5.DOI:10.13193/j.issn.1673-7717.2026.04.018
补肾活血方联合灌肠治疗慢性子宫内膜炎合并不孕症对激素、炎症水平以及妊娠结局的影响
Effect of Bushen Huoxue Formula(补肾活血方)Combined with Enema Treatment on Hormone,Inflammation Levels and Pregnancy Outcomes in Patients with Chronic Endometritis Complicated with Infertility
摘要
Abstract
Objective To observe the effects of Bushen Huoxue Formula(补肾活血方)combined with enema treatment on hormone,inflammation levels and pregnancy outcomes in patients with chronic endometritis complicated with infertility.Method A prospective study was conducted on 102 patients with chronic endometritis who received treatment at Hengshui People's Hospital from July 2022 to March 2024..The patients were divided into a control group and an observation group according to the random number table method,with 51 patients in each group.The control group received Western medicine anti infection treat-ment,while the observation group was treated with a combination of Bushen Huoxue Formula orally and traditional Chinese medi-cine enema for three consecutive menstrual cycles.The traditional Chinese medicine syndrome scores,traditional Chinese medi-cine syndrome efficacy,serum sex hormone and inflammation levels,pregnancy outcomes and adverse reactions were compared be-tween two groups.Results The total effective rate of the observation group(96.08％,49/51)was significantly better than that of the control group(84.31％,43/51),and the difference was statistically significant(P＜0.05).Before intervention,there was no significant difference in the TCM syndrome scores of the main or secondary symptoms between the two groups(P＞0.05).After intervention,compared with those of the control group,the TCM syndrome scores of the main and secondary symptoms in the ob-servation group were significantly down-regulated(P＜0.01).There was no significant difference in the levels of progesterone(P),estradiol 2(E2)or follicle stimulating hormone(FSH)between the two groups before intervention(P＞0.05).After inter-vention,the levels of P and FSH were down-regulated and the E2 levels up-regulated in the two groups and the changes of the observation group was more obvious(P＜0.01).After intervention,the levels of interleukin-1β(IL-1β),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the observation group were significantly down-regulated(P＜0.01).The incidence of adverse reactions in the observation group(15.68％,8/51)showed no significant difference compared to that in the control group(9.80％,5/51)(P＞0.05).Compared with those of the control group,the clinical pregnancy rate and embryo im-plantation rate of the observation group were significantly up-regulated(P＜0.05),while there was no significant difference in ectopic pregnancy rate,miscarriage rate or preterm birth rate between the two groups(P＞0.05).Conclusion The combination of Bushen Huoxue Formula and enema can significantly enhance the therapeutic effect,alleviate the clinical symptoms such as ab-dominal pain and menstrual disorders,regulate the hormone levels,inhibit the inflammatory reactions and improve the pregnancy outcomes of infertile patients with chronic endometritis.关键词
补肾活血方/灌肠/慢性子宫内膜炎/不孕症/激素水平/炎症/妊娠结局Key words
Bushen Huoxue Formula(补肾活血方)/enema/chronic endometritis/infertility/hormone levels/inflammation/pregnancy outcome分类
医药卫生引用本文复制引用
孟维合,李冬梅,崔家璐,赵卫国,冀雪霞,刘玮..补肾活血方联合灌肠治疗慢性子宫内膜炎合并不孕症对激素、炎症水平以及妊娠结局的影响[J].中华中医药学刊,2026,44(4):81-85,5.基金项目
国家自然科学基金项目(81400812) （81400812）
河北省中医药管理局项目(2023287) （2023287）
