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Establishment and evaluation of a stable CHO cell line in which the nanobody PD-L1-Fc gene is precisely targeted into the C12orf35 locus

Feng Chang Chen Zhang Yu Feng Wenyun Zheng Xingyuan Ma

Acta Biochimica et Biophysica Sinica2026，Vol.58Issue(2)：P.453-457,5.

Acta Biochimica et Biophysica Sinica2026，Vol.58Issue(2)：P.453-457,5.DOI:10.3724/abbs.2025187

Establishment and evaluation of a stable CHO cell line in which the nanobody PD-L1-Fc gene is precisely targeted into the C12orf35 locus

Feng Chang ¹Chen Zhang ¹Yu Feng ²Wenyun Zheng ²Xingyuan Ma¹

作者信息

1. State Key Laboratory of Bioreactor Engineering,School of Biotechnology,East China University of Science and Technology,Shanghai 200237,China
2. Shanghai Key Laboratory of New Drug Design,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China
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摘要

关键词

genetic instabilityis/incorporating genes interest genome/evaluation/manufacturing biopharmaceuticalsand/recombinant protein/cho cell lines/screening process nonethelesshighly/establishment

分类

生物科学

引用本文复制引用

Feng Chang,Chen Zhang,Yu Feng,Wenyun Zheng,Xingyuan Ma..Establishment and evaluation of a stable CHO cell line in which the nanobody PD-L1-Fc gene is precisely targeted into the C12orf35 locus[J].Acta Biochimica et Biophysica Sinica,2026,58(2):P.453-457,5.

基金项目

supported by the grants from National Key Research and Development Project of China (No. 2018YFA0902804),the National Natural Science Foundation of China (Nos. 32471003). （No. 2018YFA0902804）

Acta Biochimica et Biophysica Sinica

ISSN：1672-9145

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