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Cardiac PTN-SlRT1 axis alleviates oxidative stress and promotes mitochondrial energy reprogramming to mitigate doxorubicin-induced cardiotoxicity through AMPK/PGC1αsignaling

Yuxiao Sun Tianwen Wei Hongping Xu Hongda Li Chang Zhou Xianliang Liu Yafei Li Shangwei Huang Qi Zhang Xia Duan

Acta Biochimica et Biophysica Sinica2026，Vol.58Issue(2)：P.421-436,16.

Acta Biochimica et Biophysica Sinica2026，Vol.58Issue(2)：P.421-436,16.DOI:10.3724/abbs.2026018

Cardiac PTN-SlRT1 axis alleviates oxidative stress and promotes mitochondrial energy reprogramming to mitigate doxorubicin-induced cardiotoxicity through AMPK/PGC1αsignaling

Yuxiao Sun ¹Tianwen Wei ¹Hongping Xu ¹Hongda Li ¹Chang Zhou ²Xianliang Liu ³Yafei Li ⁴Shangwei Huang ¹Qi Zhang ¹Xia Duan⁵

作者信息

1. Department of Cardiology,Shanghai East Hospital,School of Medicine,Tongji University,Shanghai 200120,China
2. School of Medicine,Tongji University,Shanghai 200092,China
3. School of Nursing and Health Sciences,Hong Kong Metropolitan University,Hong Kong SAR,China
4. Department of Cardiology,the Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou Municipal Hospital,Gusu School,Nanjing Medical University,Suzhou 215000,China
5. Nursing Department,Shanghai Key Laboratory of Maternal Fetal Medicine,Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology,Shanghai First Maternity and Infant Hospital,School of Medicine,Tongji University,Shanghai 200092,China
折叠

摘要

关键词

doxorubicin-induced cardiotoxicity/pleiotrophin/oxidative stress/mitochondrial energy metabolism

分类

医药卫生

引用本文复制引用

Yuxiao Sun,Tianwen Wei,Hongping Xu,Hongda Li,Chang Zhou,Xianliang Liu,Yafei Li,Shangwei Huang,Qi Zhang,Xia Duan..Cardiac PTN-SlRT1 axis alleviates oxidative stress and promotes mitochondrial energy reprogramming to mitigate doxorubicin-induced cardiotoxicity through AMPK/PGC1αsignaling[J].Acta Biochimica et Biophysica Sinica,2026,58(2):P.421-436,16.

基金项目

supprorted by the grants from the National Natural Science Foundation of China(No.82170477) （No.82170477）

the Key Disciplines Group Construction Project of Shanghai Pudong New Area Health Commission(No.PWZxq2022-02) （No.PWZxq2022-02）

the Clinical Research Project of the Three-Year Action Plan for the Disciplinary Construction of the"School of Nursing(in Preparation)"of Tongji University School of Medicine(No.JS2210313) （in Preparation）

the Important Weak Subject Construction Project of Shanghai Pudong New Area Health Commission(No.PWZbr2022-04) （No.PWZbr2022-04）

Shanghai East Hospital Youth Scientific Research Cultivation Fund(No.DFPY2024020) （No.DFPY2024020）

the Angel Plan and Young Nurse Growth Project of Shanghai East Hospital(No.DFTS-2227) （No.DFTS-2227）

the Fifth Batch of Technical Standardization Management and Promotion Projects of Shanghai Hospital Development Center(No.SHDC22024211) （No.SHDC22024211）

the General Program of Shanghai Municipal Health Commission(No.202340048). （No.202340048）

Acta Biochimica et Biophysica Sinica

ISSN：1672-9145

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