安徽医科大学学报2026，Vol.61Issue(3)：432-438,7.DOI:10.19405/j.cnki.issn1000-1492.2026.03.007
木犀草素防治聚苯乙烯微塑料诱导的血管损伤机制研究
Protective effects and mechanisms of luteolin on vascular injury induced by polystyrene microplastics
摘要
Abstract
Objective To explore the vascular endothelial injury in male mice caused by exposure to polystyrene microplastics(PS-MPs)and the intervention effect of luteolin on vascular remodeling.Additionally,to investigate the mechanism through the oxidative system and metabolomics.Methods Thirty-two C57BL/6 mice(6-8 weeks old)were randomly divided into the saline group(saline group),the 0.1 mg/kg PS-MPs exposure group(0.1PS-MPs group),the 1 mg/kg PS-MPs exposure group(1PS-MPs group),and the 1 mg/kg PS-MPs+luteolin treatment group(1PS-MPs+Lut group),with 8 mice in each group.After 8 weeks of intervention,the body weight,blood pressure,aortic organ coefficient,and aortic histopathological changes of mice in each group were detected;the to-tal cholesterol(TC),triglyceride(TG),and high-density lipoprotein cholesterol(HDL-C)lipid metabolism-related indicators in the aorta of mice were detected;the reactive oxygen species(ROS),glutathione(GSH),and malondialdehyde(MDA)oxidative stress-related indicators were detected;the endothelin(ET-1),nitric oxide(NO),vascular endothelial growth factor A(VEGF-A),vascular cell adhesion molecule-1(VCAM-1/CD106),and intercellular adhesion molecule-1(ICAM-1/CD54)endothelial function-related indicators and serum metabolo-mics were detected.Results Compared to the saline group,exposure to PS-MPs resulted in pathological thicken-ing of the mouse aorta,increased aortic organ coefficient,and elevated blood pressure.Lipid metabolism-related indicators,including TC and TG,were elevated,while HDL-C was reduced,indicating lipid metabolism disorder in mice.Oxidative stress markers such as ROS and MDA increased,whereas GSH decreased,demonstrating oxida-tive damage.Vascular endothelial inflammation and injury markers,including ET-1,VEGF-A,VCAM-1,and ICAM-1,were upregulated,while the vasodilatory substance NO was downregulated,confirming endothelial in-jury.Furthermore,serum metabolomics results revealed that PS-MPs exposure induced endothelial damage by dis-rupting metabolic pathways such as the citrate cycle.Compared to the PS-MPs group,luteolin significantly re-versed these effects,attenuating oxidative stress and lipid metabolism disorders,and effectively repairing endothe-lial injury.Conclusion PS-MPs induce vascular toxicity through oxidative stress and lipid metabolism.Luteolin effectively alleviates endothelial damage and vascular remodeling.关键词
聚苯乙烯微塑料/氧化应激/血管毒性/血管内皮损伤/血管重塑/木犀草素/环境污染物Key words
polystyrene microplastics/oxidative stress/vascular toxicity/vascular endothelial injury/vascular remodeling/luteolin/environmental pollutants分类
医药卫生引用本文复制引用
朱德育,黄琪,梁潇,魏状状,鲍欣雨,马萍,武阳,鲍翠玉..木犀草素防治聚苯乙烯微塑料诱导的血管损伤机制研究[J].安徽医科大学学报,2026,61(3):432-438,7.基金项目
国家自然科学基金项目(编号:42177416) （编号:42177416）
湖北科技学院医学科研专项重点项目(编号:2022YKY01) （编号:2022YKY01）
湖北省咸宁市科技计划社发类研发重点专项(编号:2023SFYF095) （编号:2023SFYF095）
湖北省自然科学基金咸宁创新发展联合基金重点项目(编号:2025AFD389) National Natural Science Foundation of China(No.42177416) （编号:2025AFD389）
Medical Research Key Project of Hubei University of Science and Technology(No.2022YKY01) （No.2022YKY01）
Key Specialized Research Project of Science and Technology Planning of Xiangning City,Hubei Province(No.2023SFYF095) （No.2023SFYF095）
Key Project of Xianning Inno-vation and Development Joint Fund of Hubei Provincial Natural Science Foundation(No.2025AFD389) （No.2025AFD389）
