中医药临床杂志2026，Vol.38Issue(4)：652-658,7.DOI:10.16448/j.cjtcm.2026.0407
基于"肝肾同源"探讨肝因子在糖尿病视网膜病变合并肾病中的作用
Based on the Concept of"Liver and Kidney Sharing the Same Origin,"this Study Explores the Role of Liver Factors in Diabetic Retinopathy Complicated with Nephropathy
摘要
Abstract
Diabetic retinopathy(DR)and diabetic nephropathy are the two most common microvascular complica-tions of diabetes,severely impacting patients'quality of life and increasing the risk of death.Epidemiological studies have revealed that these two conditions can co-occur,exhibiting certain correlations in pathological mechanisms and treatment.This comorbidity may be closely related to common mechanisms such as long-term hyperglycemia,oxidative stress,inflammatory responses,and vascular endothelial dysfunction.In recent years,hepatokines,as a class of active substances secreted by the liver,have attracted considerable attention due to their crucial roles in regulating glucose and lipid metabolism,inflammatory responses,and vascular function.This article will discuss the pathogenesis of DR combined with nephropathy and explore the relationship between hepatokines and the disease from the perspective of the traditional Chinese medicine theory of"liver and kidney sharing the same origin."This will not only help eluci-date the comorbidity mechanism of the two complications but may also provide a theoretical basis for developing novel therapeutic strategies targeting hepatokines.This research direction is expected to provide new ideas and strategies for the prevention and treatment of diabetic microvascular complications.关键词
糖尿病视网膜病变/糖尿病肾病/肝因子/肝肾同源Key words
Diabetic retinopathy/Diabetic nephropathy/Hepatokines/Liver and kidney sharing the same origin分类
医药卫生引用本文复制引用
张邹婷,陆西宛,朱丽华,杨帆,李晓曼,赵想..基于"肝肾同源"探讨肝因子在糖尿病视网膜病变合并肾病中的作用[J].中医药临床杂志,2026,38(4):652-658,7.基金项目
国家自然科学基金(82174292) （82174292）
2021年度无锡市"太湖人才计划"支持项目(锡人才办[2021]9号-1) （锡人才办[2021]9号-1）
无锡市卫生健康委2020年度科研项目(M202008) （M202008）
中国中医药科技发展中心(国家中医药管理局人才交流中心) （国家中医药管理局人才交流中心）
2023年度第一批联合研究项目(CXZH202308) （CXZH202308）
