川北医学院学报2026，Vol.41Issue(3)：298-302,5.DOI:10.3969/j.issn.1005-3697.2026.03.007
益气养阴化痰祛瘀法联合甲巯咪唑对甲状腺功能亢进症患者糖脂代谢和甲状腺激素水平的影响
Effect of Yiqi Yangyin Huatan Quyu method combined with methimazole on glucolipid metabolism and thyroid hormones levels in patients with hyperthyroidism
摘要
Abstract
Objective:To analyze the influence of combination of Yiqi Yangyin Huatan Quyu method and methimazole on glucolipid metabolism and thyroid hormones levels in patients with hyperthyroidism.Methods:196 patients with hyperthyroidism were included and categorized into routine group and combined group,with 98 cases in each group.The routine group was treated with methimazole,whereas the combined group received Yiqi Yangyin Huatan Quyu decoction combined with methimazole.Both groups were treated continuously for 1 months.The TCM symptoms scores(anterior neck enlargement,pal-pitations,irritability,polyphagia and polydipsia),glucolipid metabolism[2 h postprandial blood glucose(2hPG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)]and thyroid hormones[free thyroxine T3(FT3),free thyroxine T4(FT4),total triiodothyronine(TT3),total thyroxine(TT4),thyroid stimulating hormone(TSH)]before and after treatment and total incidence rate of adverse drug reactions(allergic dermatitis,gastrointestinal reaction,leukopenia)during treatment were compared between both groups of patients.Results:After treatment,the scores of TCM syndromes and levels of 2hPG,FT3,FT4,TT3 and TT4 in the two groups were decreased,and the combined group had lower scores of TCM syndromes such as palpitations,irritability,and polyphagia and polydipsia as well as lower FT3 and TT3 levels(P＜0.05).There were no statistical differences in the score of anterior neck enlargement and levels of 2hPG,FT4 and TT4 between the two groups(P＞0.05).The levels of TC,LDL-C and TSH were increased in both groups,and the levels in combined group were higher(P＜0.05).No significant difference was found in the total incidence rate of adverse drug reactions between both groups during treatment(P＞0.05).Conclusion:Yiqi Yangyin Huatan Quyu method combined with methimazole has an exact effect in the treatment of patients with hyperthyroidism.Additionally,it can relieve clinical symptoms,and improve glucolipid metabolism and thyroid hormones,and it will not increase the risk of adverse drug reactions.关键词
益气养阴化痰祛瘀法/甲巯咪唑/甲状腺功能亢进症/糖脂代谢/甲状腺激素Key words
Yiqi Yangyin Huatan Quyu method/Methimazole/Hyperthyroidism/Glucolipid metabolism/Thyroid hormones分类
医药卫生引用本文复制引用
张为民,夏泽鲁,刘真如,李梦璇,温永天..益气养阴化痰祛瘀法联合甲巯咪唑对甲状腺功能亢进症患者糖脂代谢和甲状腺激素水平的影响[J].川北医学院学报,2026,41(3):298-302,5.基金项目
天津市北辰区卫健系统科技项目(SHGY-2025018) （SHGY-2025018）
